J147

J147
Legal status
Legal status
  • Investigational New Drug
Identifiers
CAS Number 1146963-51-0
PubChem (CID) 25229652
ChemSpider 29341612
Chemical and physical data
Formula C18H17F3N2O2
Molar mass 350.34 g·mol−1
3D model (Jmol) Interactive image

J147 is an experimental drug with reported effects against both Alzheimer's disease and ageing in mouse models of accelerated aging.[1][2][3][4]

The approach that lead to development of the J147 drug was to screen candidate molecules for anti-aging effects, instead of targeting the amyloid plaques. It is contrary to most other approaches to developing drugs against Alzheimer's disease that target the plaque deposits in the brain.[5]

The J147 drug is also reported to address other biological aging factors, such as preventing the leakage of blood from microvessels in mice brains.[5] The development of J147 follows the chemical pharmacological way, contrary to biological ways that exploit e.g. use of bacteriophages.[6][7]

References

  1. ↑ "Experimental drug targeting Alzheimer's disease shows anti-aging effects" (Press release). Salk Institute. 12 November 2015. Retrieved November 13, 2015.
  2. ↑ Chen Q, Prior M, Dargusch R, Roberts A, Riek R, Eichmann C, Chiruta C, Akaishi T, Abe K, Maher P, Schubert D (14 December 2011). "A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease". PLoS One. 6 (12): e27865. doi:10.1371/journal.pone.0027865. PMC 3237323Freely accessible. PMID 22194796.
  3. ↑ Currais A, Goldberg J, Farrokhi C, Chang M, Prior M, Dargusch R, Daugherty D, Armando A, Quehenberger O, Maher P, Schubert D (11 November 2015). "A comprehensive multiomics approach toward understanding the relationship between aging and dementia" (PDF). Aging. 7 (11): 937–55. doi:10.18632/aging.100838. PMC 4694064Freely accessible. PMID 26564964.
  4. ↑ Prior M, Dargusch R, Ehren JL, Chiruta C, Schubert D (May 2013). "The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice". Alzheimer's Research & Therapy. 5 (3): 25. doi:10.1186/alzrt179. PMC 3706879Freely accessible. PMID 23673233.
  5. 1 2 Brian L. Wang (13 November 2015). "Experimental drug targeting Alzheimer's disease shows anti-aging effects in animal tests". nextbigfuture.com. Retrieved November 16, 2015.
  6. ↑ Krishnan R, Tsubery H, Proschitsky MY, Asp E, Lulu M, Gilead S, Gartner M, Waltho JP, Davis PJ, Hounslow AM, Kirschner DA, Inouye H, Myszka DG, Wright J, Solomon B, Fisher RA (2014). "A bacteriophage capsid protein provides a general amyloid interaction motif (GAIM) that binds and remodels misfolded protein assemblies.". Journal of Molecular Biology. 426: 2500–19. doi:10.1016/j.jmb.2014.04.015. PMID 24768993.
  7. ↑ Solomon B (October 2008). "Filamentous bacteriophage as a novel therapeutic tool for Alzheimer's disease treatment". Journal of Alzheimer's Disease. 15 (2): 193–8. PMID 18953108.


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