Zona pellucida-like domain

Zona pellucida-like domain
Identifiers
Symbol Zona_pellucida
Pfam PF00100
InterPro IPR001507
SMART SM00241
PROSITE PDOC00577

Zona pellucida-like domain (ZP domain / ZP-like domain) is a family of evolutionarily related proteins.[1][2]

A large domain, containing around 260 amino acids, has been recognised in a variety of receptor-like eukaryotic glycoproteins.[1] All of these proteins are mosaic proteins composed of various domains and that all have a large extracellular region, often followed by either a transmembrane region and a very short cytoplasmic region or by a GPI-anchor. The domain common to all these proteins is a bipartite protein polymerization module [3][4] that is located in the C-terminal portion of the extracellular region and contains 8 or 10 conserved Cys residues involved in disulfide bonds.[5][6]

Examples

Humans genes encoding proteins containing this domain include:

References

  1. 1 2 Bork P, Sander C (April 1992). "A large domain common to sperm receptors (Zp2 and Zp3) and TGF-beta type III receptor". FEBS Lett. 300 (3): 237–40. doi:10.1016/0014-5793(92)80853-9. PMID 1313375.
  2. ↑ Jovine L, Darie CC, Litscher ES, Wassarman PM (2005). "Zona pellucida domain proteins". Annu. Rev. Biochem. 74: 83–114. doi:10.1146/annurev.biochem.74.082803.133039. PMID 15952882.
  3. ↑ Jovine L, Qi H, Williams Z, Litscher E, Wassarman PM (2002). "The ZP domain is a conserved module for polymerization of extracellular proteins". Nat Cell Biol. 4 (6): 457–61. doi:10.1038/ncb802. PMID 12021773.
  4. ↑ Jovine L, Qi H, Williams Z, Litscher ES, Wassarman PM (2004). "A duplicated motif controls assembly of zona pellucida domain proteins". Proc. Natl. Acad. Sci. U.S.A. 101 (16): 5922–7. doi:10.1073/pnas.0401600101. PMC 395899Freely accessible. PMID 15079052.
  5. ↑ Monné M, Han L, Schwend T, Burendahl S, Jovine L (2008). "Crystal structure of the ZP-N domain of ZP3 reveals the core fold of animal egg coats". Nature. 456 (7222): 653–7. doi:10.1038/nature07599. PMID 19052627. PDB: 3D4C​ PDB: 3D4G​ PDB: 3EF7​
  6. ↑ Han L, Monné M, Okumura, H, Schwend, T, Cherry, AL, Flot, D, Matsuda, T, Jovine, L (2010). "Insights into egg coat assembly and egg-sperm interaction from the X-ray structure of full-length ZP3". Cell. 143 (3): 404–15. doi:10.1016/j.cell.2010.09.041. PMID 20970175. PDB: 3NK3​ PDB: 3NK4​

This article incorporates text from the public domain Pfam and InterPro IPR001507


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