VUF-5681

VUF-5681

Names
IUPAC name 4-[3-(1H-imidazol-5-yl)propyl]piperidine
Identifiers
CAS Number	768358-61-8 Y
3D model (Jmol)	Interactive image
ChemSpider	8505701 N
PubChem	10330240
InChI InChI=1S/C11H19N3/c1(3-11-8-13-9-14-11)2-10-4-6-12-7-5-10/h8-10,12H,1-7H2,(H,13,14) N Key: YPGRNKJNOSUCLY-UHFFFAOYSA-N N InChI=1/C11H19N3/c1(3-11-8-13-9-14-11)2-10-4-6-12-7-5-10/h8-10,12H,1-7H2,(H,13,14) Key: YPGRNKJNOSUCLY-UHFFFAOYAZ
SMILES C2CNCCC2CCCc1ncnc1
Properties
Chemical formula	C11H19N3
Molar mass	193.288 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YN ?)
Infobox references

VUF-5681 is a potent and selective histamine antagonist which binds selectively to the H₃ subtype.^[1] However while VUF-5681 blocks the activity of more potent H₃ agonists, recent studies suggest that it may have some weak partial agonist activity when administered by itself.^[2]

References

1. ↑ Moreno-Delgado D, Torrent A, Gómez-Ramírez J, de Esch I, Blanco I, Ortiz J. Constitutive activity of H3 autoreceptors modulates histamine synthesis in rat brain through the cAMP/PKA pathway. Neuropharmacology. 2006 Sep;51(3):517-23. PMID 16769092
2. ↑ Baker, JG (2008). "Antagonist affinity measurements at the Gi-coupled human histamine H3 receptor expressed in CHO cells". BMC pharmacology. 8: 9. doi:10.1186/1471-2210-8-9. PMC 2430196. PMID 18538007.