Transfusion hemosiderosis

Transfusion hemosiderosis
Classification and external resources
Specialty	emergency medicine
ICD-10	T80.8
ICD-9-CM	999.8

Transfusional hemosiderosis is the accumulation of iron in the liver and/or heart but also endocrine organs, in patients who receive or did receive frequent blood transfusions (such as those with thalassemia, sickle cell disease, leukemia, aplastic anemia or myelodysplastic syndrome).

Treatment

Treatment is by phlebotomy, erythrocytapheresis or chelation therapy with iron chelating agents such as deferoxamine, deferiprone or deferasirox.^[1] If iron overload has caused end-organ damage, this is generally irreversible and may require transplantation.

Ted DeVita died of transfusional iron overload from too many blood transfusions.

↑ Hider, Robert C.; Kong, Xiaole (2013). "Chapter 8. Iron: Effect of Overload and Deficiency". In Astrid Sigel, Helmut Sigel and Roland K. O. Sigel. Interrelations between Essential Metal Ions and Human Diseases. Metal Ions in Life Sciences. 13. Springer. pp. 229–294. doi:10.1007/978-94-007-7500-8_8.

Lu JP, Hayashi K (1994). "Selective iron deposition in pancreatic islet B cells of transfusional iron-overloaded autopsy cases". Pathol Int. 44 (3): 194–9. PMID 8025661.

Complications of surgical and medical care (T80–T88, 996–999)

Transfusion reactions	Transfusion hemosiderosis TRALI TACO TA-GvHD FNHTR Acute/Delayed hemolytic transfusion reaction

Vaccine injury	Eczema vaccinatum

Other	Serum sickness Malignant hyperthermia Herxheimer reaction Graft-versus-host disease

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