TXNDC5

TXNDC5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases TXNDC5, ENDOPDI, ERP46, HCC-2, PDIA15, STRF8, UNQ364, HCC2, thioredoxin domain containing 5
External IDs MGI: 2145316 HomoloGene: 11125 GeneCards: TXNDC5
Orthologs
Species Human Mouse
Entrez

81567

105245

Ensembl

ENSG00000239264

ENSMUSG00000038991

UniProt

Q8NBS9

Q91W90

RefSeq (mRNA)

NM_030810
NM_001145549
NM_022085

NM_001289598
NM_001289599
NM_145367

RefSeq (protein)

NP_001139021.1
NP_110437.2

NP_001276527.1
NP_001276528.1
NP_663342.3

Location (UCSC) Chr 6: 7.88 – 7.91 Mb Chr 13: 38.5 – 38.53 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Thioredoxin domain-containing protein 5 is a protein that in humans is encoded by the TXNDC5 gene.[3]

Function

This gene encodes a protein disulfide-isomerase.[4] Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. This gene can be co-transcribed with the upstream gene MUTED.[3]

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. 1 2 "Entrez Gene: TXNDC5 thioredoxin domain containing 5".
  4. ↑ Galligan JJ, Petersen DR (July 2012). "The human protein disulfide isomerase gene family". Human Genomics. 6 (6): 6. doi:10.1186/1479-7364-6-6. PMC 3500226Freely accessible. PMID 23245351.

Further reading

  • Neve EP, Svensson K, Fuxe J, Pettersson RF (Aug 2003). "VIPL, a VIP36-like membrane protein with a putative function in the export of glycoproteins from the endoplasmic reticulum". Experimental Cell Research. 288 (1): 70–83. doi:10.1016/S0014-4827(03)00161-7. PMID 12878160. 
  • Knoblach B, Keller BO, Groenendyk J, Aldred S, Zheng J, Lemire BD, Li L, Michalak M (Oct 2003). "ERp19 and ERp46, new members of the thioredoxin family of endoplasmic reticulum proteins". Molecular & Cellular Proteomics. 2 (10): 1104–19. doi:10.1074/mcp.M300053-MCP200. PMID 12930873. 
  • Sullivan DC, Huminiecki L, Moore JW, Boyle JJ, Poulsom R, Creamer D, Barker J, Bicknell R (Nov 2003). "EndoPDI, a novel protein-disulfide isomerase-like protein that is preferentially expressed in endothelial cells acts as a stress survival factor". The Journal of Biological Chemistry. 278 (47): 47079–88. doi:10.1074/jbc.M308124200. PMID 12963716. 
  • Bruneel A, Labas V, Mailloux A, Sharma S, Royer N, Vinh J, Pernet P, Vaubourdolle M, Baudin B (Oct 2005). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis". Proteomics. 5 (15): 3876–84. doi:10.1002/pmic.200401239. PMID 16130169. 
  • Nissom PM, Lo SL, Lo JC, Ong PF, Lim JW, Ou K, Liang RC, Seow TK, Chung MC (Apr 2006). "Hcc-2, a novel mammalian ER thioredoxin that is differentially expressed in hepatocellular carcinoma". FEBS Letters. 580 (9): 2216–26. doi:10.1016/j.febslet.2006.03.029. PMID 16574106. 
  • Wang Y, Ma Y, Lü B, Xu E, Huang Q, Lai M (Oct 2007). "Differential expression of mimecan and thioredoxin domain-containing protein 5 in colorectal adenoma and cancer: a proteomic study". Experimental Biology and Medicine. 232 (9): 1152–9. doi:10.3181/0701-RM-8. PMID 17895523. 


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