TRPM4

Identifiers

TRPM4, PFHB1B, TRPM4B, LTrpC4, htransient receptor potential cation channel subfamily M member 4

External IDs

OMIM: 606936 MGI: 1915917 HomoloGene: 23033 GeneCards: TRPM4

Targeted by Drug

adenosine triphosphate, spermine, adenosine, adenosine phosphate, adenosine diphosphate, AMP-PNP, clotrimazole^[1]

Gene ontology
Molecular function	• nucleotide binding • calcium activated cation channel activity • calcium channel activity • calmodulin binding • ion channel activity • ATP binding • sodium channel activity
Cellular component	• integral component of membrane • Golgi apparatus • membrane • plasma membrane • nucleoplasm • endoplasmic reticulum • cytosol • neuronal cell body
Biological process	• adaptive immune response • vasoconstriction • immune system process • positive regulation of canonical Wnt signaling pathway • regulation of membrane potential • cation transport • ion transport • protein sumoylation • dendritic cell chemotaxis • regulation of T cell cytokine production • cardiac conduction • positive regulation of cell proliferation • transport • calcium ion transport • negative regulation of bone mineralization • positive regulation of atrial cardiac muscle cell action potential • positive regulation of heart rate • transmembrane transport • positive regulation of adipose tissue development • sodium ion transmembrane transport • positive regulation of cytosolic calcium ion concentration • calcium ion transmembrane transport • positive regulation of fat cell differentiation • positive regulation of insulin secretion involved in cellular response to glucose stimulus • negative regulation of osteoblast differentiation • positive regulation of vasoconstriction • positive regulation of regulation of vascular smooth muscle cell membrane depolarization • ion transmembrane transport
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


54795


68667

Ensembl


ENSG00000130529


ENSMUSG00000038260

UniProt


Q8TD43


Q7TN37

RefSeq (mRNA)

NM_001195227 NM_017636 NM_001321281 NM_001321282 NM_001321283
NM_001321285


NM_175130

RefSeq (protein)


NP_001182156.1 NP_060106.2 NP_001308212.1


NP_780339.2

Location (UCSC)

Chr 19: 49.16 – 49.21 Mb

Chr 7: 45.3 – 45.33 Mb

PubMed search

^[2]

^[3]

Wikidata

View/Edit Human

View/Edit Mouse

Transient receptor potential cation channel subfamily M member 4 (hTRPM4), also known as melastatin-4, is a protein that in humans is encoded by the TRPM4 gene.^[4]^[5]

References

↑ "Drugs that physically interact with Transient receptor potential cation channel subfamily M member 4 view/edit references on wikidata".
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Xu XZ, Moebius F, Gill DL, Montell C (September 2001). "Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform". Proc. Natl. Acad. Sci. U.S.A. 98 (19): 10692–7. doi:10.1073/pnas.191360198. PMC 58528. PMID 11535825.
↑ Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100.

External links

TRPM4 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3

Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ

Proton-gated	Amiloride-sensitive cation channel 1 2 3 4

Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1

Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1

Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18

Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker gene

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B

H⁺: Proton channel	HVCN1

M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4

M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6

H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family

Cytoplasm: Gap junction	Connexin: A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4) Innexin

By gating mechanism

Ion channel class	Ligand-gated Light-gated Voltage-gated Stretch-activated

see also disorders

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TRPM4

See also

References

Further reading

External links