TKTL1

TKTL1

Identifiers

TKTL1, TKR, TKT2, transketolase-like 1, transketolase like 1

External IDs

MGI: 1933244 HomoloGene: 8169 GeneCards: TKTL1

Gene ontology
Molecular function	• transferase activity • catalytic activity • metal ion binding • transketolase activity
Cellular component	• cytoplasm • nucleus
Biological process	• thiamine metabolic process • metabolic process • glucose catabolic process
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


8277


83553


ENSG00000007350


ENSMUSG00000031397


P51854


Q99MX0

RefSeq (mRNA)


NM_012253 NM_001145933 NM_001145934


NM_031379

RefSeq (protein)


NP_001139406.1 NP_036385.3


NP_113556.2

Location (UCSC)

Chr X: 154.3 – 154.33 Mb

Chr X: 74.18 – 74.21 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

Transketolase-like protein 1 is an enzyme that in humans is encoded by the TKTL1 gene.^[3]^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Coy JF, Dubel S, Kioschis P, Thomas K, Micklem G, Delius H, Poustka A (Feb 1997). "Molecular cloning of tissue-specific transcripts of a transketolase-related gene: implications for the evolution of new vertebrate genes". Genomics. 32 (3): 309–16. doi:10.1006/geno.1996.0124. PMID 8838793.
↑ "Entrez Gene: TKTL1 transketolase-like 1".

Further reading

Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
Coy JF, Dressler D, Wilde J, Schubert P (2005). "Mutations in the transketolase-like gene TKTL1: clinical implications for neurodegenerative diseases, diabetes and cancer". Clin. Lab. 51 (5–6): 257–73. PMID 15991799.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Langbein S, Zerilli M, Zur Hausen A, et al. (2006). "Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted". Br. J. Cancer. 94 (4): 578–85. doi:10.1038/sj.bjc.6602962. PMC 2361175. PMID 16465194.
Staiger WI, Coy JF, Grobholz R, et al. (2007). "Expression of the mutated transketolase TKTL1, a molecular marker in gastric cancer". Oncol. Rep. 16 (4): 657–61. doi:10.3892/or.16.4.657. PMID 16969476.
Zhang S, Yang JH, Guo CK, Cai PC (2007). "Gene silencing of TKTL1 by RNAi inhibits cell proliferation in human hepatoma cells". Cancer Lett. 253 (1): 108–14. doi:10.1016/j.canlet.2007.01.010. PMID 17321041.

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