TJP3

TJP3

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3KFV

Identifiers

TJP3, ZO-3, ZO3, tight junction protein 3

External IDs

MGI: 1351650 HomoloGene: 8458 GeneCards: TJP3

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


27134


27375


ENSG00000105289


ENSMUSG00000034917


O95049


Q9QXY1

RefSeq (mRNA)


NM_014428 NM_001267560 NM_001267561


NM_001282095 NM_001282096 NM_013769

RefSeq (protein)


NP_001254489.1 NP_001254490.1


n/a

Location (UCSC)

Chr 19: 3.71 – 3.75 Mb

Chr 10: 81.27 – 81.29 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

Tight junction protein ZO-3 is a protein that in humans is encoded by the TJP3 gene.^[3]

Interactions

TJP3 has been shown to interact with Tight junction protein 1.^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ "Entrez Gene: TJP3 tight junction protein 3 (zona occludens 3)".
↑ Wittchen, E S; Haskins J; Stevenson B R (Dec 1999). "Protein interactions at the tight junction. Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3". J. Biol. Chem. UNITED STATES. 274 (49): 35179–85. doi:10.1074/jbc.274.49.35179. ISSN 0021-9258. PMID 10575001.

Further reading

Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Roh MH, Liu CJ, Laurinec S, Margolis B (2002). "The carboxyl terminus of zona occludens-3 binds and recruits a mammalian homologue of discs lost to tight junctions.". J. Biol. Chem. 277 (30): 27501–9. doi:10.1074/jbc.M201177200. PMID 12021270.
Kausalya PJ, Reichert M, Hunziker W (2001). "Connexin45 directly binds to ZO-1 and localizes to the tight junction region in epithelial MDCK cells.". FEBS Lett. 505 (1): 92–6. doi:10.1016/S0014-5793(01)02786-7. PMID 11557048.
Itoh M, Furuse M, Morita K, et al. (2000). "Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins.". J. Cell Biol. 147 (6): 1351–63. doi:10.1083/jcb.147.6.1351. PMC 2168087. PMID 10601346.
Wittchen ES, Haskins J, Stevenson BR (2000). "Protein interactions at the tight junction. Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3.". J. Biol. Chem. 274 (49): 35179–85. doi:10.1074/jbc.274.49.35179. PMID 10575001.
Haskins J, Gu L, Wittchen ES, et al. (1998). "ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludin.". J. Cell Biol. 141 (1): 199–208. doi:10.1083/jcb.141.1.199. PMC 2132714. PMID 9531559.

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