TAF1B

TAF1B
Identifiers
Aliases	TAF1B, MGC:9349, RAF1B, RAFI63, SL1, TAFI63, TATA-box binding protein associated factor, RNA polymerase I subunit B
External IDs	MGI: 109577 HomoloGene: 31331 GeneCards: TAF1B
Gene ontology Molecular function • DNA binding • transcription factor activity, sequence-specific DNA binding • metal ion binding • protein binding • TBP-class protein binding • RNA polymerase I CORE element sequence-specific DNA binding • transcription factor activity, RNA polymerase I CORE element binding transcription factor recruiting Cellular component • nucleoplasm • RNA polymerase transcription factor SL1 complex • nucleolus • extracellular exosome • nucleus • RNA polymerase I core factor complex Biological process • termination of RNA polymerase I transcription • positive regulation of gene expression, epigenetic • regulation of transcription, DNA-templated • transcription initiation from RNA polymerase I promoter • RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript • transcription, DNA-templated • transcription elongation from RNA polymerase I promoter • transcription from RNA polymerase I promoter • RNA polymerase I transcriptional preinitiation complex assembly Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9014	21340
Ensembl	ENSG00000115750	ENSMUSG00000059669
UniProt	Q53T94	P97358
RefSeq (mRNA)	NM_005680 NM_001318976 NM_001318977	NM_020614
RefSeq (protein)	NP_005671.2 NP_001305905.1	NP_065639.2
Location (UCSC)	Chr 2: 9.84 – 9.93 Mb	Chr 12: 24.5 – 24.56 Mb
PubMed search	[1]	[2]
Wikidata

TATA box-binding protein-associated factor RNA polymerase I subunit B is an enzyme that in humans is encoded by the TAF1B gene.^[3][4]

Function

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes one of the SL1-specific TAFs.^[4]

Interactions

TAF1B has been shown to interact with RRN3.^[5]

References

Further reading