Streptolydigin
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| Clinical data | |
|---|---|
| ATC code | none |
| Identifiers | |
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| CAS Number |
7229-50-7  |
| PubChem (CID) | 220508 |
| DrugBank |
DB04785  |
| ChemSpider |
16736035 |
| ChEBI |
CHEBI:45773 |
| ChEMBL |
CHEMBL1236068 |
| Chemical and physical data | |
| Formula | C32H44N2O9 |
| Molar mass | 600.708 g/mol |
| 3D model (Jmol) | Interactive image |
| |
| |
| (what is this?) (verify) | |
Streptolydigin (Stl) is an antibiotic that works by inhibiting nucleic acid chain elongation by binding to RNA polymerase, thus inhibiting RNA synthesis inside a cell.[1][2][3] Streptolydigin inhibits bacterial RNA polymerase, but not eukaryotic RNA polymerase.[4] It has antibacterial activity against a number of Gram positive bacteria.
References
- ↑ Tuske, S.; Sarafianos, S.; Wang, X.; Hudson, B.; Sineva, E.; Mukhopadhyay, J.; Birktoft, J.; Leroy, O.; Ismail, S.; Clark, A.; Dharia, C.; Napoli, A.; Laptenko, O.; Lee, J.; Borokhov, S.; Arnold, E.; Ebright, R. (2005). "Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation". Cell. 122 (4): 541–552. doi:10.1016/j.cell.2005.07.017. PMC 2754413
. PMID 16122422. - ↑ Temiakov, D; Zenkin, N; Vassylyeva, M. N.; Perederina, A; Tahirov, T. H.; Kashkina, E; Savkina, M; Zorov, S; Nikiforov, V; Igarashi, N; Matsugaki, N; Wakatsuki, S; Severinov, K; Vassylyev, D. G. (2005). "Structural basis of transcription inhibition by antibiotic streptolydigin". Molecular Cell. 19 (5): 655–66. doi:10.1016/j.molcel.2005.07.020. PMID 16167380.
- ↑ Vassylyev, D. G.; Vassylyeva, M. N.; Zhang, J; Palangat, M; Artsimovitch, I; Landick, R (2007). "Structural basis for substrate loading in bacterial RNA polymerase". Nature. 448 (7150): 163–8. doi:10.1038/nature05931. PMID 17581591.
- ↑ Tuske, S.; Sarafianos, S.; Wang, X.; Hudson, B.; Sineva, E.; Mukhopadhyay, J.; Birktoft, J.; Leroy, O.; Ismail, S.; Clark, A.; Dharia, C.; Napoli, A.; Laptenko, O.; Lee, J.; Borokhov, S.; Arnold, E.; Ebright, R. (2005). "Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation". Cell. 122 (4): 541–552. doi:10.1016/j.cell.2005.07.017. PMC 2754413. PMID 16122422.
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