Secnidazole

Secnidazole
Clinical data

AHFS/Drugs.com	International Drug Names
Routes of administration	Oral
ATC code	P01AB07 (WHO)
Identifiers
IUPAC name 1-(2-Methyl-5-nitro-1H-imidazol-1-yl)propan-2-ol
Synonyms	PM 185184, RP 14539
CAS Number	3366-95-8^N
PubChem (CID)	71815
ChemSpider	64839^Y
UNII	R3459K699K^Y
KEGG	D07353^Y
ChEMBL	CHEMBL498847^Y
ECHA InfoCard	100.020.123
Chemical and physical data
Formula	C₇H₁₁N₃O₃
Molar mass	185.180 g/mol
3D model (Jmol)	Interactive image
SMILES [O-][N+](=O)c1cnc(n1CC(O)C)C
InChI InChI=1S/C7H11N3O3/c1-5(11)4-9-6(2)8-3-7(9)10(12)13/h3,5,11H,4H2,1-2H3^Y Key:KPQZUUQMTUIKBP-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)

Secnidazole (trade names Flagentyl, Sindose, Secnil) is a nitroimidazole anti-infective. Effectiveness in the treatment of dientamoebiasis has been reported.^[1] It has also been tested against Atopobium vaginae.^[2]

References

↑ Girginkardeşler, N.; Coşkun, S.; Cüneyt Balcioğlu, I.; Ertan, P.; Ok, U. Z. (2003). "Dientamoeba fragilis, a neglected cause of diarrhea, successfully treated with secnidazole". Clinical Microbiology and Infection. 9 (2): 110–113. doi:10.1046/j.1469-0691.2003.00504.x. PMID 12588330.
↑ De Backer, E.; Dubreuil, L.; Brauman, M.; Acar, J.; Vaneechoutte, M. (2009). "In vitro activity of secnidazole against Atopobium vaginae, an anaerobic pathogen involved in bacterial vaginosis". Clinical Microbiology and Infection. 16 (5): 470–472. doi:10.1111/j.1469-0691.2009.02852.x. PMID 19548924.

Gillis, J. C.; Wiseman, L. R. (1996). "Secnidazole. A review of its antimicrobial activity, pharmacokinetic properties and therapeutic use in the management of protozoal infections and bacterial vaginosis". Drugs. 51 (4): 621–38. doi:10.2165/00003495-199651040-00007. PMID 8706597.

Nitroimidazole derivatives	Metronidazole^# Tinidazole Ornidazole Nimorazole Secnidazole Azanidazole Propenidazole

Other	isoquinoline (Emetine/Dehydroemetine)

Hydroxyquinoline derivatives	Cl (Chlorquinaldol) Br (Tilbroquinol Broxyquinoline) I (Diiodohydroxyquinoline) I, Cl (Clioquinol) related: Chiniofon

Dichloroacetamide derivatives	Diloxanide^# Clefamide Etofamide Teclozan

Aminoglycoside	Paromomycin

Other/ungrouped

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