SLC25A29

Solute carrier family 25, member 29 is a protein that in humans is encoded by the SLC25A29 gene.[1] The gene is also known as CACL and C14orf69.[1] SLC25A29 belongs to a protein family of solute carriers called the mitochondrial carriers.[1]

Model organisms

Model organisms have been used in the study of SLC25A29 function. A conditional knockout mouse line, called Slc25a29tm1a(KOMP)Wtsi[6][7] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[8][9][10]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[4][11] Twenty four tests were carried out on mutant mice, but no significant abnormalities were observed.[4]

References

  1. 1 2 3 "Solute carrier family 25, member 29". Retrieved 2011-12-05.
  2. ↑ "Salmonella infection data for Slc25a29". Wellcome Trust Sanger Institute.
  3. ↑ "Citrobacter infection data for Slc25a29". Wellcome Trust Sanger Institute.
  4. 1 2 3 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x.
  5. ↑ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  6. ↑ "International Knockout Mouse Consortium".
  7. ↑ "Mouse Genome Informatics".
  8. ↑ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410Freely accessible. PMID 21677750.
  9. ↑ Dolgin E (June 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  10. ↑ Collins FS; Rossant J; Wurst W (January 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  11. ↑ van der Weyden L; White JK; Adams DJ; Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837Freely accessible. PMID 21722353.

Further reading

  • Camacho, J. E. A.; Rioseco-Camacho, N. (2009). "The Human and Mouse SLC25A29 Mitochondrial Transporters Rescue the Deficient Ornithine Metabolism in Fibroblasts of Patients with the Hyperornithinemia-Hyperammonemia-Homocitrullinuria (HHH) Syndrome". Pediatric Research. 66 (1): 35–41. doi:10.1203/PDR.0b013e3181a283c1. PMID 19287344. 
  • Sekoguchi, E.; Sato, N.; Yasui, A.; Fukada, S.; Nimura, Y.; Aburatani, H.; Ikeda, K.; Matsuura, A. (2003). "A Novel Mitochondrial Carnitine-acylcarnitine Translocase Induced by Partial Hepatectomy and Fasting". Journal of Biological Chemistry. 278 (40): 38796–38802. doi:10.1074/jbc.M306372200. PMID 12882971. 


This article is issued from Wikipedia - version of the 6/5/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.