RivX sRNA
| RivX | |
|---|---|
 | |
| Predicted secondary structure of RivX sRNA | |
| Identifiers | |
| Symbol | RivX |
| Other data | |
| RNA type | sRNA |
| Domain(s) | Streptococcus pyogenes |
RivX sRNA is a non-coding RNA molecule involved in the interface between two key regulators of virulence in the human pathogen Streptococcus pyogenes (Group A Streptoccus, also known as GAS): the CovR/S system[1] and Mga regulator.[2] This RNA, along with its downstream protein-coding gene RivR, are the first discovered links between these two important regulation networks.[2] An extra protein linking the two pathways, TrxR, was described a year later.[3] The adjoining of these two pathways could allow a consistently high virulence of S. pyogenes despite a variety of environmental conditions.[2]
RivX is thought to be co-transcribed with RivR mRNA before post-transcriptional processing releases the sRNA. It was found to be a non-coding transcript through site-directed mutagenesis experimentation.[2]
In total, the GAS genome is now predicted to encode 75 total sRNAs, a number approximately equal to the number of transcription factors encoded by the genome, which shows the importance of RNA regulation in GAS.[4]
References
- ↑ Churchward, G (Apr 2007). "The two faces of Janus: virulence gene regulation by CovR/S in group A streptococci.". Molecular Microbiology. 64 (1): 34–41. doi:10.1111/j.1365-2958.2007.05649.x. PMID 17376070.
- 1 2 3 4 Roberts, SA; Scott, JR (Dec 2007). "RivR and the small RNA RivX: the missing links between the CovR regulatory cascade and the Mga regulon.". Molecular Microbiology. 66 (6): 1506–22. doi:10.1111/j.1365-2958.2007.06015.x. PMID 18005100.
- ↑ Leday, TV; Gold, KM; Kinkel, TL; Roberts, SA; Scott, JR; McIver, KS (Oct 2008). "TrxR, a new CovR-repressed response regulator that activates the Mga virulence regulon in group A Streptococcus.". Infection and immunity. 76 (10): 4659–68. doi:10.1128/IAI.00597-08. PMC 2546847
. PMID 18678666. - ↑ Perez, N; Treviño, J; Liu, Z; Ho, SC; Babitzke, P; Sumby, P (2009-11-02). "A genome-wide analysis of small regulatory RNAs in the human pathogen group A Streptococcus.". PLoS ONE. 4 (11): e7668. doi:10.1371/journal.pone.0007668. PMC 2765633. PMID 19888332.