RRAD

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2DPX, 2GJS, 3Q72, 3Q7P, 3Q7Q

Identifiers

Aliases

RRAD, RAD, RAD1, REM3, Ras related glycolysis inhibitor and calcium channel regulator

External IDs

MGI: 1930943 HomoloGene: 3071 GeneCards: RRAD

Gene ontology
Molecular function	• nucleotide binding • GTP binding • protein binding • GTPase activity • calmodulin binding
Cellular component	• plasma membrane • membrane • intracellular
Biological process	• small GTPase mediated signal transduction • signal transduction
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


6236


56437

Ensembl


ENSG00000166592


ENSMUSG00000031880

UniProt


P55042


O88667

RefSeq (mRNA)


NM_004165 NM_001128850


NM_019662

RefSeq (protein)


NP_001122322.1 NP_004156.1


n/a

Location (UCSC)

Chr 16: 66.92 – 66.93 Mb

Chr 8: 104.63 – 104.63 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

GTP-binding protein RAD is a protein that in humans is encoded by the RRAD gene.^[3]^[4]

Interactions

RRAD has been shown to interact with CAMK2G^[5] and TPM2.^[6]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Doria A, Caldwell JS, Ji L, Reynet C, Rich SS, Weremowicz S, Morton CC, Warram JH, Kahn CR, Krolewski AS (March 1995). "Trinucleotide repeats at the rad locus. Allele distributions in NIDDM and mapping to a 3-cM region on chromosome 16q". Diabetes. 44 (2): 243–7. doi:10.2337/diabetes.44.2.243. PMID 7859947.
↑ "Entrez Gene: RRAD Ras-related associated with diabetes".
↑ Moyers JS, Bilan PJ, Zhu J, Kahn CR (May 1997). "Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II". J. Biol. Chem. 272 (18): 11832–9. doi:10.1074/jbc.272.18.11832. PMID 9115241.
↑ Zhu J, Bilan PJ, Moyers JS, Antonetti DA, Kahn CR (January 1996). "Rad, a novel Ras-related GTPase, interacts with skeletal muscle beta-tropomyosin". J. Biol. Chem. 271 (2): 768–73. doi:10.1074/jbc.271.2.768. PMID 8557685.

Zhu J, Reynet C, Caldwell JS, Kahn CR (1995). "Characterization of Rad, a new member of Ras/GTPase superfamily, and its regulation by a unique GTPase-activating protein (GAP)-like activity". J. Biol. Chem. 270 (9): 4805–12. doi:10.1074/jbc.270.9.4805. PMID 7876254.
Reynet C, Kahn CR (1993). "Rad: a member of the Ras family overexpressed in muscle of type II diabetic humans". Science. 262 (5138): 1441–4. doi:10.1126/science.8248782. PMID 8248782.
Zhu J, Bilan PJ, Moyers JS, Antonetti DA, Kahn CR (1996). "Rad, a novel Ras-related GTPase, interacts with skeletal muscle beta-tropomyosin". J. Biol. Chem. 271 (2): 768–73. doi:10.1074/jbc.271.2.768. PMID 8557685.
Caldwell JS, Moyers JS, Doria A, Reynet C, Kahn RC (1996). "Molecular cloning of the human rad gene: gene structure and complete nucleotide sequence". Biochim. Biophys. Acta. 1316 (3): 145–8. doi:10.1016/0925-4439(96)00034-8. PMID 8781531.
Moyers JS, Bilan PJ, Reynet C, Kahn CR (1996). "Overexpression of Rad inhibits glucose uptake in cultured muscle and fat cells". J. Biol. Chem. 271 (38): 23111–6. doi:10.1074/jbc.271.38.23111. PMID 8798502.
Moyers JS, Bilan PJ, Zhu J, Kahn CR (1997). "Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II". J. Biol. Chem. 272 (18): 11832–9. doi:10.1074/jbc.272.18.11832. PMID 9115241.
Moyers JS, Zhu J, Kahn CR (1998). "Effects of phosphorylation on function of the Rad GTPase". Biochem. J. 333 ( Pt 3) (3): 609–14. PMC 1219623. PMID 9677319.
Finlin BS, Andres DA (1999). "Phosphorylation-dependent association of the Ras-related GTP-binding protein Rem with 14-3-3 proteins". Arch. Biochem. Biophys. 368 (2): 401–12. doi:10.1006/abbi.1999.1316. PMID 10441394.
Zhu J, Tseng YH, Kantor JD, Rhodes CJ, Zetter BR, Moyers JS, Kahn CR (1999). "Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation". Proc. Natl. Acad. Sci. U.S.A. 96 (26): 14911–8. doi:10.1073/pnas.96.26.14911. PMC 24747. PMID 10611312.
Tseng YH, Vicent D, Zhu J, Niu Y, Adeyinka A, Moyers JS, Watson PH, Kahn CR (2001). "Regulation of growth and tumorigenicity of breast cancer cells by the low molecular weight GTPase Rad and nm23". Cancer Res. 61 (5): 2071–9. PMID 11280768.
Yanuar A, Sakurai S, Kitano K, Hakoshima T (2005). "Expression, purification, crystallization and preliminary crystallographic analysis of human Rad GTPase". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 61 (Pt 11): 978–80. doi:10.1107/S1744309105031982. PMC 1978125. PMID 16511212.
Yanuar A, Sakurai S, Kitano K, Hakoshima T (2006). "Crystal structure of human Rad GTPase of the RGK-family". Genes Cells. 11 (8): 961–8. doi:10.1111/j.1365-2443.2006.00994.x. PMID 16866878.
Suzuki M, Shigematsu H, Shames DS, Sunaga N, Takahashi T, Shivapurkar N, Iizasa T, Minna JD, Fujisawa T, Gazdar AF (2007). "Methylation and gene silencing of the Ras-related GTPase gene in lung and breast cancers". Ann. Surg. Oncol. 14 (4): 1397–404. doi:10.1245/s10434-006-9089-6. PMID 17195088.
Yada H, Murata M, Shimoda K, Yuasa S, Kawaguchi H, Ieda M, Adachi T, Murata M, Ogawa S, Fukuda K (2007). "Dominant negative suppression of Rad leads to QT prolongation and causes ventricular arrhythmias via modulation of L-type Ca2+ channels in the heart". Circ. Res. 101 (1): 69–77. doi:10.1161/CIRCRESAHA.106.146399. PMID 17525370.
Szafranski K, Schindler S, Taudien S, Hiller M, Huse K, Jahn N, Schreiber S, Backofen R, Platzer M (2007). "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns". Genome Biol. 8 (8): R154. doi:10.1186/gb-2007-8-8-r154. PMC 2374985. PMID 17672918.

PDB gallery

2dpx: Crystal Structure of human Rad GTPase

2gjs: The crystal structure of human RRAD in complex with GDP

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RRAD

Interactions

References

Further reading