RIPK1

RIPK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4ITH, 4ITI, 4ITJ, 4NEU, 5HX6
Identifiers
Aliases	RIPK1, RIP, RIP1, RIP-1, receptor interacting serine/threonine kinase 1
External IDs	MGI: 108212 HomoloGene: 2820 GeneCards: RIPK1
Gene ontology Molecular function • transferase activity • protein kinase activity • nucleotide binding • death receptor binding • death domain binding • protein complex binding • kinase activity • protein serine/threonine kinase activity • protein binding • identical protein binding • ATP binding • ubiquitin protein ligase binding Cellular component • cytoplasm • cytosol • membrane • ripoptosome • receptor complex • plasma membrane • protein complex • mitochondrion • death-inducing signaling complex • membrane raft Biological process • T cell apoptotic process • positive regulation of protein phosphorylation • amyloid fibril formation • positive regulation of cell death • activation of JUN kinase activity • protein heterooligomerization • phosphorylation • regulation of ATP:ADP antiporter activity • peptidyl-serine autophosphorylation • regulation of tumor necrosis factor-mediated signaling pathway • positive regulation of macrophage differentiation • cellular response to tumor necrosis factor • cellular response to growth factor stimulus • activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway • negative regulation of extrinsic apoptotic signaling pathway • positive regulation of programmed cell death • tumor necrosis factor-mediated signaling pathway • positive regulation of JNK cascade • regulation of reactive oxygen species metabolic process • cellular protein catabolic process • negative regulation of I-kappaB kinase/NF-kappaB signaling • regulation of necrotic cell death • TRIF-dependent toll-like receptor signaling pathway • response to tumor necrosis factor • positive regulation of necroptotic process • protein phosphorylation • positive regulation of reactive oxygen species metabolic process • death-inducing signaling complex assembly • positive regulation of NF-kappaB transcription factor activity • necroptotic signaling pathway • positive regulation of interleukin-8 production • positive regulation of tumor necrosis factor production • positive regulation of apoptotic process • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of extrinsic apoptotic signaling pathway • protein autophosphorylation • regulation of extrinsic apoptotic signaling pathway via death domain receptors • ripoptosome assembly involved in necroptotic process • necroptotic process • positive regulation of phosphorylation • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • I-kappaB kinase/NF-kappaB signaling • activation of cysteine-type endopeptidase activity involved in apoptotic process • protein homooligomerization • positive regulation of transcription from RNA polymerase II promoter • ripoptosome assembly • signal transduction • positive regulation of MAPK cascade • positive regulation of hydrogen peroxide-induced cell death • apoptotic signaling pathway • apoptotic process • programmed cell death • extrinsic apoptotic signaling pathway • positive regulation of necrotic cell death • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8737	19766
Ensembl	ENSG00000137275	ENSMUSG00000021408
UniProt	Q13546	Q60855
RefSeq (mRNA)	NM_003804 NM_001317061	NM_009068
RefSeq (protein)	NP_003795.2 NP_001303990.1	NP_033094.3
Location (UCSC)	Chr 6: 3.06 – 3.12 Mb	Chr 13: 34 – 34.04 Mb
PubMed search	[1]	[2]
Wikidata

Receptor-interacting serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the RIPK1 gene.^[3][4][5] RIPK1 is known to have function in a variety of cellular pathways including the NF-κB pathway and programmed necrotic cell death (necroptosis).

Function

Although, RIPK1 has been primarily studied in the context of TNFR signaling, RIPk1 is also activated in response to diverse stimuli.^[6]

The kinase domain, while important for necroptotic (programmed necrotic) functions, it appears dispensable for pro-survival roles. Kinase activity of RIPK1 is also required for RIPK1-dependent apoptosis in conditions of IAP1/2 depletion, TAK1inhibition/depletion, RIPK3 depletion or MLKL depletion.^[7][8] Also, proteolytic processing of RIPk1, through both caspase-dependent and -independent mechanisms, triggers lethality that is dependent on the generation of one or more specific C-terminal cleavage product(s) of RIPk1 upon stress.

Interactions

RIPK1 has been shown to interact with:

• BIRC2,^[9]
• BIRC3,^[9]
• CA11,^[10]
• CASP8,^[9][11][12]
• CFLAR,^[11][13]
• CRADD,^[14][15]
• RIPK3,^[16][17]
• RNF11,^[18]
• RNF216,^[19]
• SQSTM1,^[20]
• TNFRSF1A,^{[4][14][21][22][23][24]}
• TRADD,^[4]
• TRAF2,^{[4][25][26][27]} and
• UBC.^{[9][10][23][24][28]}

References

Further reading