RGS18

RGS18
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases RGS18, RGS13, regulator of G-protein signaling 18
External IDs MGI: 1927498 HomoloGene: 11281 GeneCards: RGS18
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

64407

64214

Ensembl

ENSG00000150681

ENSMUSG00000026357

UniProt

Q9NS28

Q99PG4

RefSeq (mRNA)

NM_130782

NM_022881

RefSeq (protein)

NP_570138.1

NP_075019.1

Location (UCSC) Chr 1: 192.16 – 192.19 Mb Chr 1: 144.75 – 144.78 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Regulator of G-protein signaling 18 is a protein that in humans is encoded by the RGS18 gene.[3][4]

Function

This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[4]

Interactions

RGS18 has been shown to interact with GNAI3.[5][6]

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. ↑ Park IK, Klug CA, Li K, Jerabek L, Li L, Nanamori M, Neubig RR, Hood L, Weissman IL, Clarke MF (Jan 2001). "Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells". The Journal of Biological Chemistry. 276 (2): 915–23. doi:10.1074/jbc.M005947200. PMID 11042171.
  4. 1 2 "Entrez Gene: RGS18 regulator of G-protein signalling 18".
  5. ↑ Yowe D, Weich N, Prabhudas M, Poisson L, Errada P, Kapeller R, Yu K, Faron L, Shen M, Cleary J, Wilkie TM, Gutierrez-Ramos C, Hodge MR (Oct 2001). "RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes". The Biochemical Journal. 359 (Pt 1): 109–18. doi:10.1042/bj3590109. PMC 1222126Freely accessible. PMID 11563974.
  6. ↑ Gagnon AW, Murray DL, Leadley RJ (Jul 2002). "Cloning and characterization of a novel regulator of G protein signalling in human platelets". Cellular Signalling. 14 (7): 595–606. doi:10.1016/S0898-6568(02)00012-8. PMID 11955952.

Further reading

  • Nagata Y, Oda M, Nakata H, Shozaki Y, Kozasa T, Todokoro K (May 2001). "A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes". Blood. 97 (10): 3051–60. doi:10.1182/blood.V97.10.3051. PMID 11342430. 
  • Yowe D, Weich N, Prabhudas M, Poisson L, Errada P, Kapeller R, Yu K, Faron L, Shen M, Cleary J, Wilkie TM, Gutierrez-Ramos C, Hodge MR (Oct 2001). "RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes". The Biochemical Journal. 359 (Pt 1): 109–18. doi:10.1042/bj3590109. PMC 1222126Freely accessible. PMID 11563974. 
  • Sierra DA, Gilbert DJ, Householder D, Grishin NV, Yu K, Ukidwe P, Barker SA, He W, Wensel TG, Otero G, Brown G, Copeland NG, Jenkins NA, Wilkie TM (Feb 2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human". Genomics. 79 (2): 177–85. doi:10.1006/geno.2002.6693. PMID 11829488. 
  • Gagnon AW, Murray DL, Leadley RJ (Jul 2002). "Cloning and characterization of a novel regulator of G protein signalling in human platelets". Cellular Signalling. 14 (7): 595–606. doi:10.1016/S0898-6568(02)00012-8. PMID 11955952. 
  • Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. 
  • Larminie C, Murdock P, Walhin JP, Duckworth M, Blumer KJ, Scheideler MA, Garnier M (Mar 2004). "Selective expression of regulators of G-protein signaling (RGS) in the human central nervous system". Brain Research. Molecular Brain Research. 122 (1): 24–34. doi:10.1016/j.molbrainres.2003.11.014. PMID 14992813. 
  • Aldenhoven J, Chen Y, Moran C (2006). "Assignment of UCK2, ATF3 and RGS18 from human chromosome 1 to porcine chromosomes 4, 9 and 10 with somatic and radiation hybrid panels". Cytogenetic and Genome Research. 112 (3-4): 341F. doi:10.1159/000089896. PMID 16484797. 
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