RAET1L

Retinoic acid early transcript 1L (RAET1L) is a cell surface glycoprotein encoded by RAET1L gene located on the chromosome 6.[1] RAET1L is related to MHC class I molecules, but its gene maps outside the MHC locus.[1] RAET1L is composed of the α1α2 domain and is linked to the cell membrane by the GPI anchor.[1][2] It functions as a stress-induced ligand for NKG2D receptor.[2] Its expression is, for example, triggered in course of HCMV infection, but HCMV alters its function.[2] HCMV-encoded UL16 glycoprotein retains ULBP6 inside the cells, preventing it from reaching the cell surface and being exposed to cells of the immune system.[2]

References

  1. 1 2 3 Radosavljevic, Mirjana; Cuillerier, Benoı̂t; Wilson, Michael J.; Clément, Oliver; Wicker, Sophie; Gilfillan, Susan; Beck, Stephan; Trowsdale, John; Bahram, Seiamak (2002-01-01). "A Cluster of Ten Novel MHC Class I Related Genes on Human Chromosome 6q24.2–q25.3". Genomics. 79 (1): 114–123. doi:10.1006/geno.2001.6673. PMID 11827464.
  2. 1 2 3 4 Eagle, Robert A.; Traherne, James A.; Hair, James R.; Jafferji, Insiya; Trowsdale, John (2009-11-01). "ULBP6/RAET1L is an additional human NKG2D ligand". European Journal of Immunology. 39 (11): 3207–3216. doi:10.1002/eji.200939502. ISSN 1521-4141.


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