RAB6C

RAB6C

Identifiers

RAB6C, WTH3, member RAS oncogene family

External IDs

HomoloGene: 108091 GeneCards: RAB6C

Gene ontology
Molecular function	• nucleotide binding • GTP binding • GTPase activity
Cellular component	• cytoplasm • centrosome • Golgi apparatus • intracellular • cytoskeleton • nucleus • microtubule organizing center • cytosol
Biological process	• small GTPase mediated signal transduction • regulation of centrosome duplication • retrograde transport, endosome to Golgi • intra-Golgi vesicle-mediated transport • cell cycle process • retrograde vesicle-mediated transport, Golgi to ER • response to drug
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


84084


n/a


ENSG00000222014


n/a


Q9H0N0


n/a

RefSeq (mRNA)


NM_032144


n/a

RefSeq (protein)


NP_115520.2


n/a

Location (UCSC)

Chr 2: 129.98 – 129.98 Mb

n/a

PubMed search

^[1]

n/a

View/Edit Human

Ras-related protein Rab-6C is a protein that in humans is encoded by the RAB6C gene.^[2]^[3]^[4]

References

↑ "Human PubMed Reference:".
↑ Shan J, Mason JM, Yuan L, Barcia M, Porti D, Calabro A, Budman D, Vinciguerra V, Xu H (Dec 2000). "Rab6c, a new member of the rab gene family, is involved in drug resistance in MCF7/AdrR cells". Gene. 257 (1): 67–75. doi:10.1016/S0378-1119(00)00395-4. PMID 11054569.
↑ Tian K, Wang Y, Xu H (May 2007). "WTH3 is a direct target of the p53 protein". Br J Cancer. 96 (10): 1579–86. doi:10.1038/sj.bjc.6603724. PMC 2359938. PMID 17426708.
↑ "Entrez Gene: RAB6C RAB6C, member RAS oncogene family".

Further reading

"Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.
Fitzgerald ML, Reed GL (1999). "Rab6 is phosphorylated in thrombin-activated platelets by a protein kinase C-dependent mechanism: effects on GTP/GDP binding and cellular distribution". Biochem. J. 342 ( Pt 2) (2): 353–60. doi:10.1042/0264-6021:3420353. PMC 1220472. PMID 10455022.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Shan J, Yuan L, Budman DR, Xu HP (2002). "WTH3, a new member of the Rab6 gene family, and multidrug resistance". Biochim. Biophys. Acta. 1589 (2): 112–23. doi:10.1016/S0167-4889(02)00164-7. PMID 12007787.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Tian K, Jurukovski V, Wang XP, et al. (2005). "Epigenetic regulation of WTH3 in primary and cultured drug-resistant breast cancer cells". Cancer Res. 65 (21): 10024–31. doi:10.1158/0008-5472.CAN-05-1944. PMID 16267028.

PDB gallery

1yzq: GppNHp-Bound Rab6 GTPase

2gil: Structure of the extremely slow GTPase Rab6A in the GTP bound form at 1.8 resolution

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