RAB33B

RAB33B

Identifiers

RAB33B, SMC2, member RAS oncogene family

External IDs

MGI: 1330805 HomoloGene: 9642 GeneCards: RAB33B

Gene ontology
Molecular function	• GTPase activity • protein binding • nucleotide binding • GTP binding
Cellular component	• extracellular exosome • membrane • Golgi lumen • Golgi apparatus • Golgi membrane
Biological process	• negative regulation of constitutive secretory pathway • protein targeting to Golgi • small GTPase mediated signal transduction • regulation of Golgi organization • intra-Golgi vesicle-mediated transport • regulation of epithelial cell proliferation • regulation of retrograde vesicle-mediated transport, Golgi to ER • protein transport • transport • skeletal system morphogenesis • autophagy • regulation of cell growth • regulation of autophagosome assembly
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


83452


19338


ENSG00000172007


ENSMUSG00000027739


Q9H082


O35963

RefSeq (mRNA)


NM_031296


NM_016858

RefSeq (protein)


NP_112586.1


NP_058554.1

Location (UCSC)

Chr 4: 139.45 – 139.48 Mb

Chr 3: 51.48 – 51.5 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

Ras-related protein Rab-33B is a protein that in humans is encoded by the RAB33B gene.^[3]

Mutations in this gene have been associated to cases of Dyggve-Melchior-Clausen syndrome.^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Template:Cite web RAB33B, member RAS oncogene family
↑ Alshammari MJ, Al-Otaibi L, Alkuraya FS (May 2012). "Mutation in RAB33B, which encodes a regulator of retrograde Golgi transport, defines a second Dyggve-Melchior-Clausen locus". J Med Genet. 49 (7): 455–61. doi:10.1136/jmedgenet-2011-100666. PMID 22652534.

Further reading

Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science. 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Valsdottir R, Hashimoto H, Ashman K, et al. (2001). "Identification of rabaptin-5, rabex-5, and GM130 as putative effectors of rab33b, a regulator of retrograde traffic between the Golgi apparatus and ER.". FEBS Lett. 508 (2): 201–9. doi:10.1016/S0014-5793(01)02993-3. PMID 11718716.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Zheng JY, Koda T, Fujiwara T, et al. (1998). "A novel Rab GTPase, Rab33B, is ubiquitously expressed and localized to the medial Golgi cisternae.". J. Cell. Sci. 111 (8): 1061–9. PMID 9512502.

PDB gallery

1z06: GppNHp-Bound Rab33 GTPase

2g77: Crystal Structure of Gyp1 TBC domain in complex with Rab33 GTPase bound to GDP and AlF3

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