RAB22A

RAB22A

Identifiers

External IDs

MGI: 105072 HomoloGene: 10782 GeneCards: RAB22A

Gene ontology
Molecular function	• nucleotide binding • GDP binding • GTP binding • protein binding • GTPase activity
Cellular component	• endosome • late endosome • phagocytic vesicle membrane • cell projection • membrane • ruffle • plasma membrane • cytoplasmic, membrane-bounded vesicle • early endosome • phagocytic vesicle • actin cytoskeleton • endosome membrane • extracellular exosome • cytoplasmic vesicle
Biological process	• endocytosis • small GTPase mediated signal transduction • endosome organization • regulation of vesicle size • transport • protein transport
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


57403


19334


ENSG00000124209


ENSMUSG00000027519


Q9UL26


P35285

RefSeq (mRNA)


NM_020673


NM_024436

RefSeq (protein)


NP_065724.1


NP_077756.2

Location (UCSC)

Chr 20: 58.31 – 58.37 Mb

Chr 2: 173.66 – 173.71 Mb

PubMed search

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View/Edit Human

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Ras-related protein Rab-22A is a protein that in humans is encoded by the RAB22A gene.^[3]

The protein encoded by this gene is a member of the RAB family of small GTPases. The GTP-bound form of the encoded protein has been shown to interact with early-endosomal antigen 1, and may be involved in the trafficking of and interaction between endosomal compartments.^[3]

References

Further reading

Bao S, Zhu J, Garvey WT (1999). "Cloning of Rab GTPases expressed in human skeletal muscle: studies in insulin-resistant subjects". Horm. Metab. Res. 30 (11): 656–662. doi:10.1055/s-2007-978953. PMID 9918381.
Bucci C, Chiariello M, Lattero D, et al. (1999). "Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1)". Biochem. Biophys. Res. Commun. 258 (3): 657–662. doi:10.1006/bbrc.1999.0651. PMID 10329441.
Opdam FJ, Kamps G, Croes H, et al. (2000). "Expression of Rab small GTPases in epithelial Caco-2 cells: Rab21 is an apically located GTP-binding protein in polarised intestinal epithelial cells". Eur. J. Cell Biol. 79 (5): 308–316. doi:10.1078/S0171-9335(04)70034-5. PMID 10887961.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–871. doi:10.1038/414865a. PMID 11780052.
Kauppi M, Simonsen A, Bremnes B, et al. (2002). "The small GTPase Rab22 interacts with EEA1 and controls endosomal membrane trafficking". J. Cell. Sci. 115 (Pt 5): 899–911. PMID 11870209.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Seet LF, Liu N, Hanson BJ, Hong W (2004). "Endofin recruits TOM1 to endosomes". J. Biol. Chem. 279 (6): 4670–4679. doi:10.1074/jbc.M311228200. PMID 14613930.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Weigert R, Yeung AC, Li J, Donaldson JG (2005). "Rab22a regulates the recycling of membrane proteins internalized independently of clathrin". Mol. Biol. Cell. 15 (8): 3758–3770. doi:10.1091/mbc.E04-04-0342. PMC 491835. PMID 15181155.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Mesa R, Magadán J, Barbieri A, et al. (2005). "Overexpression of Rab22a hampers the transport between endosomes and the Golgi apparatus". Exp. Cell Res. 304 (2): 339–353. doi:10.1016/j.yexcr.2004.11.017. PMID 15748882.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–1625. doi:10.1126/science.1105776. PMID 15761153.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514.
Magadán JG, Barbieri MA, Mesa R, et al. (2006). "Rab22a regulates the sorting of transferrin to recycling endosomes". Mol. Cell. Biol. 26 (7): 2595–2614. doi:10.1128/MCB.26.7.2595-2614.2006. PMC 1430328. PMID 16537905.

PDB gallery

1yvd: GppNHp-Bound Rab22 GTPase

1z0j: Structure of GTP-Bound Rab22Q64L GTPase in complex with the minimal Rab binding domain of Rabenosyn-5

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