Quinfamide

Quinfamide
Clinical data
Routes of
administration
Oral
ATC code None
Identifiers
CAS Number 62265-68-3 N
PubChem (CID) 71743
ChemSpider 64787 N
UNII O1ZB1046R1 YesY
ECHA InfoCard 100.057.690
Chemical and physical data
Formula C16H13Cl2NO4
Molar mass 354.18472 g/mol
3D model (Jmol) Interactive image
 NYesY (what is this?)  (verify)

Quinfamide, is a drug that has anti-parasitic properties.[1]

Synthesis

Quinfamide is one of a relatively small family of antiamoebic compounds containing a dichloroacetamide function.

Quinfamide synthesis:[2][3]

The synthesis begins by amidation of 6-hydroxytetrahydroquinoline with dichloroacetyl chloride. The sequence is completed by acylation with 2-furoyl chloride.

References

  1. Davila-Gutierrez, CE.; Vasquez, C.; Trujillo-Hernandez, B.; Huerta, M. (Mar 2002). "Nitazoxanide compared with quinfamide and mebendazole in the treatment of helminthic infections and intestinal protozoa in children". Am J Trop Med Hyg. 66 (3): 251–4. PMID 12139216.
  2. D. M. Bailey, U.S. Patent 3,997,542 (1976 to Sterling).
  3. Bailey, Denis M.; Mount, Eldridge M.; Siggins, James; Carlson, John A.; Yarinsky, Allen; Slighter, Ralph G. (1979). "1-(Dichloroacetyl)-1,2,3,4-tetrahydro-6-quinolinol esters. New potent antiamebic agents". Journal of Medicinal Chemistry. 22 (5): 599. doi:10.1021/jm00191a031. PMID 458814.
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