Pyrrole-2-carboxylate decarboxylase

Pyrrole-2-carboxylate decarboxylase (EC 4.1.1.93) is an enzyme with systematic name pyrrole-2-carboxylate carboxy-lyase.^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

(1) pyrrole-2-carboxylate

\rightleftharpoons

pyrrole + CO₂

(2) pyrrole-2-carboxylate + H₂O

\rightleftharpoons

pyrrole + HCO₃⁻

The enzyme catalyses both the carboxylation and decarboxylation reactions.

References

↑ Wieser, M.; Fujii, N.; Yoshida, T.; Nagasawa, T. (1998). "Carbon dioxide fixation by reversible pyrrole-2-carboxylate decarboxylase from Bacillus megaterium PYR2910". Eur. J. Biochem. 257: 495–499. doi:10.1046/j.1432-1327.1998.2570495.x. PMID 9826198.
↑ Omura, H.; Wieser, M.; Nagasawa, T. (1998). "Pyrrole-2-carboxylate decarboxylase from Bacillus megaterium PYR2910, an organic-acid-requiring enzyme". Eur. J. Biochem. 253: 480–484. doi:10.1046/j.1432-1327.1998.2530480.x. PMID 9654100.
↑ Wieser, M.; Yoshida, T.; Nagasawa, T. (1998). "Microbial synthesis of pyrrole-2-carboxylate by Bacillus megaterium PYR2910". Tetrahedron Lett. 39: 4309–4310. doi:10.1016/s0040-4039(98)00718-7.

Carbon-carbon lyases (EC 4.1)

4.1.1: Carboxy-lyases	Acetoacetate decarboxylase Adenosylmethionine decarboxylase Aromatic L-amino acid decarboxylase Glutamate decarboxylase Histidine decarboxylase Lysine decarboxylase Malonyl-CoA decarboxylase Ornithine decarboxylase Oxaloacetate decarboxylase Phosphoenolpyruvate carboxykinase Phosphoenolpyruvate carboxylase Phosphoribosylaminoimidazole carboxylase Pyrophosphomevalonate decarboxylase Pyruvate decarboxylase RuBisCO Uridine monophosphate synthetase/Orotidine 5'-phosphate decarboxylase Uroporphyrinogen III decarboxylase

4.1.2: Aldehyde-lyases	Fructose-bisphosphate aldolase Aldolase A Aldolase B Aldolase C 2-hydroxyphytanoyl-CoA lyase Threonine aldolase

4.1.3: Oxo-acid-lyases	Isocitrate lyase 3-hydroxy-3-methylglutaryl-CoA lyase

4.1.99: Other	Tryptophanase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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