Pyrimidine oxygenase
| Pyrimidine oxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.99.46 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Pyrimidine oxygenase (EC 1.14.99.46, RutA) is an enzyme with systematic name uracil,FMNH2:oxygen oxidoreductase (uracil hydroxylating, ring-opening) .[1][2] This enzyme catalyses the following chemical reaction
- (1) uracil + FMNH2 + O2 (Z)-3-ureidoacrylate peracid + FMN
- (2) thymine + FMNH2 + O2 (Z)-2-methylureidoacrylate peracid + FMN
In vitro the product (Z)-3-ureidoacrylate peracid is spontaneously reduced to ureidoacrylate.
References
- ↑ Mukherjee, T.; Zhang, Y.; Abdelwahed, S.; Ealick, S.E.; Begley, T.P. (2010). "Catalysis of a flavoenzyme-mediated amide hydrolysis". J. Am. Chem. Soc. 132 (16): 5550–5551. doi:10.1021/ja9107676. PMC 2873085
. PMID 20369853. - ↑ Kim, K.S.; Pelton, J.G.; Inwood, W.B.; Andersen, U.; Kustu, S.; Wemmer, D.E. (2010). "The Rut pathway for pyrimidine degradation: novel chemistry and toxicity problems". J. Bacteriol. 192 (16): 4089–4102. doi:10.1128/JB.00201-10. PMC 2916427. PMID 20400551.
External links
- Pyrimidine oxygenase at the US National Library of Medicine Medical Subject Headings (MeSH)
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