Suprofen
Clinical data | |
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AHFS/Drugs.com | Micromedex Detailed Consumer Information |
Pregnancy category |
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Routes of administration | Oral, eye drops |
ATC code | M01AE07 (WHO) |
Legal status | |
Legal status |
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Pharmacokinetic data | |
Protein binding | 20% |
Identifiers | |
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CAS Number | 40828-46-4 |
PubChem (CID) | 5359 |
IUPHAR/BPS | 7298 |
DrugBank | DB00870 |
ChemSpider | 5166 |
UNII | 988GU2F9PE |
KEGG | D00452 |
ChEBI | CHEBI:9362 |
ChEMBL | CHEMBL956 |
ECHA InfoCard | 100.050.071 |
Chemical and physical data | |
Formula | C14H12O3S |
Molar mass | 260.309 g/mol |
3D model (Jmol) | Interactive image |
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Suprofen is a non-steroidal anti-inflammatory drug (NSAID) developed by Janssen Pharmaceutica[1] that was marketed as 1% eye drops under the trade name Profenal.
Uses
Suprofen was originally used as tablet, but oral uses have been discontinued due to renal effects.[2] It was subsequently used exclusively as a topical ophthalmic solution, typically to prevent miosis during and after ophthalmic surgery.[3] This application has been discontinued as well, at least in the US.[4]
References
- ↑ Janssen, Paul A.; Van Daele, Georges H. P.; Boey, Jozef M. "Antiphlogistic aroyl-substituted phenylacetic acid derivatives" (1974) DE 2353357
- ↑ Nies A S (1988). "Renal effects of nonsteroidal anti-inflammatory drugs". Agents and actions. 24: 95–106. doi:10.1007/978-3-0348-9160-8_9. PMID 3142236.
- ↑ Guidance for FDA Staff and Industry Compliance Policy Guides Manual, Sec. 460.200
- ↑ Drugs.com: suprofen ophthalmic
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