Suprofen

Suprofen
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
Pregnancy
category
  • US: C (Risk not ruled out)
Routes of
administration
Oral, eye drops
ATC code M01AE07 (WHO)
Legal status
Legal status
  • Discontinued
Pharmacokinetic data
Protein binding 20%
Identifiers
CAS Number 40828-46-4 YesY
PubChem (CID) 5359
IUPHAR/BPS 7298
DrugBank DB00870 YesY
ChemSpider 5166 N
UNII 988GU2F9PE YesY
KEGG D00452 YesY
ChEBI CHEBI:9362 N
ChEMBL CHEMBL956 N
ECHA InfoCard 100.050.071
Chemical and physical data
Formula C14H12O3S
Molar mass 260.309 g/mol
3D model (Jmol) Interactive image
 NYesY (what is this?)  (verify)

Suprofen is a non-steroidal anti-inflammatory drug (NSAID) developed by Janssen Pharmaceutica[1] that was marketed as 1% eye drops under the trade name Profenal.

Uses

Suprofen was originally used as tablet, but oral uses have been discontinued due to renal effects.[2] It was subsequently used exclusively as a topical ophthalmic solution, typically to prevent miosis during and after ophthalmic surgery.[3] This application has been discontinued as well, at least in the US.[4]

References

  1. Janssen, Paul A.; Van Daele, Georges H. P.; Boey, Jozef M. "Antiphlogistic aroyl-substituted phenylacetic acid derivatives" (1974) DE 2353357
  2. Nies A S (1988). "Renal effects of nonsteroidal anti-inflammatory drugs". Agents and actions. 24: 95–106. doi:10.1007/978-3-0348-9160-8_9. PMID 3142236.
  3. Guidance for FDA Staff and Industry Compliance Policy Guides Manual, Sec. 460.200
  4. Drugs.com: suprofen ophthalmic


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