Pregnanetriol

Pregnanetriol

Names
IUPAC name (3R,5R,8R,9S,10S,13S,14S,17R)-17-[(1S)-1-hydroxyethyl]-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthrene-3,17-diol
Other names 5β-Pregnane-3α,17α,20α-triol
Identifiers
CAS Number	1098-45-9 N
3D model (Jmol)	Interactive image
ChemSpider	92121 Y
ECHA InfoCard	100.012.862
PubChem	101967
InChI InChI=1S/C21H36O3/c1-13(22)21(24)11-8-18-16-5-4-14-12-15(23)6-9-19(14,2)17(16)7-10-20(18,21)3/h13-18,22-24H,4-12H2,1-3H3/t13-,14+,15+,16+,17-,18-,19-,20-,21-/m0/s1 Y Key: SCPADBBISMMJAW-UHHUKTEYSA-N Y InChI=1/C21H36O3/c1-13(22)21(24)11-8-18-16-5-4-14-12-15(23)6-9-19(14,2)17(16)7-10-20(18,21)3/h13-18,22-24H,4-12H2,1-3H3/t13-,14+,15+,16+,17-,18-,19-,20-,21-/m0/s1 Key: SCPADBBISMMJAW-UHHUKTEYBG
SMILES O[C@H]4C[C@@H]3[C@]([C@@H]1[C@H]([C@H]2[C@](C)(CC1)[C@@](O)([C@@H](O)C)CC2)CC3)(C)CC4
Properties
Chemical formula	C21H36O3
Molar mass	336.52 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Pregnanetriol, or 5β-pregnane-3α,17α,20α-triol is a steroid and inactive metabolite of progesterone.

Urine testing

Urine excretion of pregnanetriol can be measured over a period of 24 hours. Elevated urine pregnanetriol levels suggest adrenogenital syndrome. In monitoring treatment with cortisol replacement, elevated urine pregnanetriol levels indicate insufficient dosage of cortisol.^[1]

Reference ranges

For females:^[1]

• 0 to 5 years: < 0.1 mg/24 hours
• 6 to 9 years: < 0.3 mg/24 hours
• 10 to 15 years: 0.1 to 0.6 mg/24 hours
• 16 years and older: 0 to 1.4 mg/ 24 hours.

For males:^[1]

• 0 to 5 years: < 0.1 mg/24 hours
• 6 to 9 years: < 0.3 mg/24 hours
• 10 to 15 years: 0.2 to 0.6 mg/24 hours
• 16 years and older: 0.2 to 2 mg/ 24 hours

References