Polymorphous low-grade adenocarcinoma
| Polymorphous low-grade adenocarcinoma | |
|---|---|
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| Low magnification micrograph of a polymorphous low-grade adenocarcinoma, showing the typical variation of architectural arrangement. H&E stain. | |
| Classification and external resources |
Polymorphous low-grade adenocarcinoma, often abbreviated PLGA, is a rare, asymptomatic, slow-growing malignant salivary gland tumor.[1] It is most commonly found in the palate.[2]
The name of the tumor derives from the fact that:
- It has a varied microscopic architectural appearance, i.e. it is polymorphous.
- It is non-aggressive when compared to other oral cavity tumors, i.e. it is a low-grade tumor.[1]
- It forms glands, i.e. it is an adenocarcinoma.
It affects the minor salivary glands in the area between the hard and the soft palate. Male to female ratio is 3:1, and the average age is 56 years.
Histology
Micrograph of a polymorphous low-grade adenocarcinoma. H&E stain.
PLGAs consist of a monomorphous cell population that has a varied histologic morphology.
Microscopically, its histology can be confused with an adenoid cystic carcinoma and a pleomorphic adenoma.
Treatment
PLGAs are treated with wide local surgical excision and long-term follow-up.[2] There is a recurrence rate of 14% (Peterson, contemporary of oral and maxillofacial surgery).
Additional images
Polymorphous low-grade adenocarcinoma. H&E stain.
Additional reading
- Kahn, Michael A. Basic Oral and Maxillofacial Pathology. Volume 1. 2001.
References
- 1 2 Arathi N, Bage AM (2009). "Polymorphous low-grade adenocarcinoma of parotid gland: a rare occurrence". Indian J Pathol Microbiol. 52 (1): 103–5. doi:10.4103/0377-4929.44985. PMID 19136798.
- 1 2 Paleri V, Robinson M, Bradley P (April 2008). "Polymorphous low-grade adenocarcinoma of the head and neck". Curr Opin Otolaryngol Head Neck Surg. 16 (2): 163–9. doi:10.1097/MOO.0b013e3282f70441. PMID 18327037.
External links
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