PinT small RNA

In bacteria, PinT small RNA is a small regulatory RNA (sRNA) that is activated during stress and virulence conditions. sRNAs base-pair with target mRNAs and modulate their stability or translation. The expression of PhoP-activated sRNA called PinT is highly induced during Salmonella enterica infection. PinT temporally controls Salmonella virulence genes. On bacterial internalization it controls the expression of invasion associated effectors (SPI-1) through the direct base-pairing with the mRNA. Later in infection it represses the virulence genes (SPI-2) allowing the switch from an invasive state to the state of intracellular replication.[1]

References

  1. ↑ Westermann, AJ; Forster, KU; Amman, F; Barquist, L; Chao, Y; Schulte, L; Muller, L; Reinhart, R; Stadler, PF; Vogel, J (2016). "Dual RNA-seq unveils noncoding RNA functions in host-pathogen interactions". Nature. 529 (7587): 496–501. doi:10.1038/nature16547. PMID 26789254.
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