Phosphosulfolactate synthase
phosphosulfolactate synthase | |||||||||
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Identifiers | |||||||||
EC number | 4.4.1.19 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / EGO | ||||||||
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In enzymology, a phosphosulfolactate synthase (EC 4.4.1.19) is an enzyme that catalyzes the chemical reaction
- (2R)-2-O-phospho-3-sulfolactate phosphoenolpyruvate + hydrogen sulfite
Hence, this enzyme has one substrate, (2R)-2-O-phospho-3-sulfolactate, and two products, phosphoenolpyruvate and hydrogen sulfite.
This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme class is (2R)-2-O-phospho-3-sulfolactate hydrogen-sulfite-lyase (phosphoenolpyruvate-forming). Other names in common use include (2R)-phospho-3-sulfolactate synthase, and (2R)-O-phospho-3-sulfolactate sulfo-lyase.
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1U83.
References
- Graham DE, Xu H, White RH (2002). "Identification of coenzyme M biosynthetic phosphosulfolactate synthase: a new family of sulfonate-biosynthesizing enzymes". J. Biol. Chem. 277 (16): 13421–9. doi:10.1074/jbc.M201011200. PMID 11830598.
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