Pentachlorophenol monooxygenase
| Pentachlorophenol monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.13.50 | ||||||||
| CAS number | 136111-57-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Pentachlorophenol monooxygenase (EC 1.14.13.50, pentachlorophenol dechlorinase, pentachlorophenol dehalogenase, pentachlorophenol 4-monooxygenase, PCP hydroxylase, pentachlorophenol hydroxylase, PcpB, PCB 4-monooxygenase, PCB4MO) is an enzyme with systematic name pentachlorophenol,NADPH:oxygen oxidoreductase (hydroxylating, dechlorinating).[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- (1) pentachlorophenol + 2 NADPH + H+ + O2 2,3,5,6-tetrachlorohydroquinone + 2 NADP+ + chloride + H2O
- (2) 2,3,5,6-tetrachlorophenol + NADPH + H+ + O2 2,3,5,6-tetrachlorohydroquinone + NADP+ + H2O
Pentachlorophenol monooxygenase is a flavoprotein (FAD).
References
- ↑ Schenk, T.; Müller, R.; Mörsberger, F.; Otto, M.K.; Lingens, F. (1989). "Enzymatic dehalogenation of pentachlorophenol by extracts from Arthrobacter sp. strain ATCC 33790". J. Bacteriol. 171 (10): 5487–5491. PMC 210388
. PMID 2793827. - ↑ Xun, L.; Topp, E.; Orser, C.S. (1992). "Diverse substrate range of a Flavobacterium pentachlorophenol hydroxylase and reaction stoichiometries". J. Bacteriol. 174 (9): 2898–2902. PMC 205942. PMID 1569020.
- ↑ Xun, L.; Topp, E.; Orser, C.S. (1992). "Confirmation of oxidative dehalogenation of pentachlorophenol by a Flavobacterium pentachlorophenol hydroxylase". J. Bacteriol. 174 (17): 5745–5747. PMC 206524. PMID 1512208.
- ↑ Lange, C.C.; Schneider, B.J.; Orser, C.S. (1996). "Verification of the role of PCP 4-monooxygenase in chlorine elimination from pentachlorophenol by Flavobacterium sp. strain ATCC 39723". Biochem. Biophys. Res. Commun. 219 (1): 146–149. doi:10.1006/bbrc.1996.0196. PMID 8619798.
- ↑ Nakamura, T.; Motoyama, T.; Hirono, S.; Yamaguchi, I. (2004). "Identification, characterization, and site-directed mutagenesis of recombinant pentachlorophenol 4-monooxygenase". Biochim. Biophys. Acta. 1700 (2): 151–159. doi:10.1016/j.bbapap.2004.04.008. PMID 15262224.
External links
- Pentachlorophenol monooxygenase at the US National Library of Medicine Medical Subject Headings (MeSH)
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