PDE7A

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1ZKL, 3G3N, 4PM0, 4Y2B

Identifiers

Aliases

PDE7A, HCP1, PDE7, phosphodiesterase 7A

External IDs

MGI: 1202402 HomoloGene: 1956 GeneCards: PDE7A

Targeted by Drug

brl-50481^[1]

Gene ontology
Molecular function	• hydrolase activity • metal ion binding • phosphoric diester hydrolase activity • 3',5'-cyclic-nucleotide phosphodiesterase activity • 3',5'-cyclic-AMP phosphodiesterase activity
Cellular component	• cytosol • cytoplasm
Biological process	• cAMP catabolic process • signal transduction
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


5150


18583

Ensembl


ENSG00000205268


ENSMUSG00000069094

UniProt


Q13946


P70453

RefSeq (mRNA)


NM_001242318 NM_002603 NM_002604


NM_001122759 NM_008802

RefSeq (protein)


NP_001229247.1 NP_002594.1


NP_001116231.1 NP_032828.2

Location (UCSC)

Chr 8: 65.72 – 65.84 Mb

Chr 3: 19.22 – 19.31 Mb

PubMed search

^[2]

^[3]

Wikidata

View/Edit Human

View/Edit Mouse

High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A is an enzyme that in humans is encoded by the PDE7A gene.^[4]^[5]^[6]

References

↑ "Drugs that physically interact with High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A view/edit references on wikidata".
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Michaeli T, Bloom TJ, Martins T, Loughney K, Ferguson K, Riggs M, Rodgers L, Beavo JA, Wigler M (Jul 1993). "Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae". J Biol Chem. 268 (17): 12925–32. PMID 8389765.
↑ Han P, Fletcher CF, Copeland NG, Jenkins NA, Yaremko LM, Michaeli T (Jun 1998). "Assignment of the mouse Pde7A gene to the proximal region of chromosome 3 and of the human PDE7A gene to chromosome 8q13". Genomics. 48 (2): 275–6. doi:10.1006/geno.1997.5168. PMID 9521885.
↑ "Entrez Gene: PDE7A phosphodiesterase 7A".

Milatovich A, Bolger G, Michaeli T, Francke U (1994). "Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse.". Somat. Cell Mol. Genet. 20 (2): 75–86. doi:10.1007/BF02290677. PMID 8009369.
Han P, Zhu X, Michaeli T (1997). "Alternative splicing of the high affinity cAMP-specific phosphodiesterase (PDE7A) mRNA in human skeletal muscle and heart.". J. Biol. Chem. 272 (26): 16152–7. doi:10.1074/jbc.272.26.16152. PMID 9195912.
Zhou L, Thompson WJ, Potter DE (1999). "Multiple cyclic nucleotide phosphodiesterases in human trabecular meshwork cells.". Invest. Ophthalmol. Vis. Sci. 40 (8): 1745–52. PMID 10393044.
Miró X, Casacuberta JM, Gutiérrez-López MD, de Landázuri MO, Puigdomènech P (2000). "Phosphodiesterases 4D and 7A splice variants in the response of HUVEC cells to TNF-alpha(1)". Biochem. Biophys. Res. Commun. 274 (2): 415–21. doi:10.1006/bbrc.2000.3146. PMID 10913353.
Zauli G, Milani D, Mirandola P, Mazzoni M, Secchiero P, Miscia S, Capitani S (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964.
Glavas NA, Ostenson C, Schaefer JB, Vasta V, Beavo JA (2001). "T cell activation up-regulates cyclic nucleotide phosphodiesterases 8A1 and 7A3". Proc. Natl. Acad. Sci. U.S.A. 98 (11): 6319–24. doi:10.1073/pnas.101131098. PMC 33466. PMID 11371644.
Lee R, Wolda S, Moon E, Esselstyn J, Hertel C, Lerner A (2002). "PDE7A is expressed in human B-lymphocytes and is up-regulated by elevation of intracellular cAMP". Cell. Signal. 14 (3): 277–84. doi:10.1016/S0898-6568(01)00250-9. PMID 11812656.
Nakata A, Ogawa K, Sasaki T, Koyama N, Wada K, Kotera J, Kikkawa H, Omori K, Kaminuma O (2002). "Potential role of phosphodiesterase 7 in human T cell function: comparative effects of two phosphodiesterase inhibitors". Clin. Exp. Immunol. 128 (3): 460–6. doi:10.1046/j.1365-2249.2002.01856.x. PMC 1906253. PMID 12067300.
Smith SJ, Brookes-Fazakerley S, Donnelly LE, Barnes PJ, Barnette MS, Giembycz MA (2003). "Ubiquitous expression of phosphodiesterase 7A in human proinflammatory and immune cells". Am. J. Physiol. Lung Cell Mol. Physiol. 284 (2): L279–89. doi:10.1152/ajplung.00170.2002 (inactive 2015-01-01). PMID 12388353.
Torras-Llort M, Azorín F (2003). "Functional characterization of the human phosphodiesterase 7A1 promoter". Biochem. J. 373 (Pt 3): 835–43. doi:10.1042/BJ20021829. PMC 1223549. PMID 12737631.
Wang H, Liu Y, Chen Y, Robinson H, Ke H (2005). "Multiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7". J. Biol. Chem. 280 (35): 30949–55. doi:10.1074/jbc.M504398200. PMID 15994308.
Sánchez AI, Meneses R, Mínguez JM, Núñez A, Castillo RR, Filace F, Burgos C, Vaquero JJ, Álvarez-Builla J, Cortés-Cabrera A, Gago F, Terricabras E, Segarra V (2014). "Microwave-assisted synthesis of potent PDE7 inhibitors containing a thienopyrimidin-4-amine scaffold". Org. Biomol. Chem. 12 (24): 4233–42. doi:10.1039/c4ob00175c. PMID 24838636.

PDB gallery

1zkl: Multiple Determinants for Inhibitor Selectivity of Cyclic Nucleotide Phosphodiesterases

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PDE7A

References

Further reading