Disufenton sodium
Clinical data | |
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ATC code | none |
Identifiers | |
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PubChem (CID) | 6440181 |
ChemSpider | 28530805 |
UNII | 7M1J3HN9VO |
KEGG | D03875 |
ChEMBL | CHEMBL1627056 |
Chemical and physical data | |
Formula | C11H13NNa2O7S2 |
Molar mass | 381.33 g/mol |
3D model (Jmol) | Interactive image |
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Disufenton sodium (NXY-059, Cerovive) is the disulfonyl derivative of the neuroprotective spin trap phenylbutylnitrone or "PBN". It was under development at the drug company AstraZeneca. A 2005 phase-3 clinical trial[1][2] called "SAINT-1" reported some efficacy in the acute treatment of ischemia injury due to stroke. However, a 2006 attempt to repeat this trial indicated no significant activity. After ruling out other causes, the authors tentatively attributed the positive results in the first trial to "chance".[1] AstraZeneca then terminated the development programme.[3] PBN and its derivatives hydrolyze and oxidize in vitro to form respectively MNP-OH (AKA, NtBHA) and its parent spin-trap MNP.
References
- 1 2 Lees, Kennedy R.; Zivin, Justin A.; Ashwood, Tim; Davalos, Antonio; Davis, Stephen M.; Diener, Hans-Christoph; Grotta, James; Lyden, Patrick; et al. (2006). "NXY-059 for Acute Ischemic Stroke". New England Journal of Medicine. 354 (6): 588–600. doi:10.1056/NEJMoa052980. PMID 16467546.
- ↑ Lees, KR; Davalos, A; Davis, SM; Diener, HC; Grotta, J; Lyden, P; Shuaib, A; Ashwood, T; et al. (2006). "Additional outcomes and subgroup analyses of NXY-059 for acute ischemic stroke in the SAINT I trial". Stroke; a journal of cerebral circulation. 37 (12): 2970–8. doi:10.1161/01.STR.0000249410.91473.44. PMID 17068304.
- ↑ Renovis: Press Release
External links
- Oxidants, antioxidants and the ischemic brain
- NXY-059: Review of Neuroprotective Potential for Acute Stroke
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