NADH:ubiquinone reductase (Na+-transporting)

NADH:ubiquinone reductase (Na⁺-transporting) (EC 1.6.5.8 is an enzyme with systematic name NADH:ubiquinone oxidoreductase (Na⁺-translocating). In bacteria, three different types of respiratory NADH:quinone oxidoreductases (NQr) have been described: the electrogenic complex I, also called NDH I in bacteria, the non-electrogenic NADH:quinone oxidoreductases (NDH II), and the Na⁺-translocating NADH:quinone oxidoreductases Na⁺-NQr. The common function of these membrane-bound enzymes in respiration is to oxidize NADH using ubiquinone (Q) as electron acceptor. The net reaction thus yields ubiquinol (QH2), the reducing substrate of enzyme complexes further along the respiratory chain, and NAD⁺, which is used as oxidizing agent in numerous cellular processes.^[1]

NADH + H⁺ + ubiquinone + n Na⁺in → NAD⁺ + ubiquinol + n Na⁺out

The enzyme is iron-sulfur flavoprotein.

References

↑ Fritz, Günter; Steuber, Julia (2016). "Chapter 11. Sodium as Coupling Cation in Respiratory Energy Conversion". In Astrid, Sigel; Helmut, Sigel; Roland K.O., Sigel. The Alkali Metal Ions: Their Role in Life. Metal Ions in Life Sciences. 16. Springer. pp. 349–390. doi:10.1007/978-4-319-21756-7_11.

External links

NADH:ubiquinone reductase (Na -transporting) at the US National Library of Medicine Medical Subject Headings (MeSH)

Oxidoreductases: NADH or NADPH (EC 1.6)

1.6.1: NAD/NADP	NAD(P)⁺ transhydrogenase (Si-specific) NAD(P)⁺ transhydrogenase (Re/Si-specific)

1.6.2: Heme	Methemoglobin reductase NADPH—hemoprotein reductase/Cytochrome P450 reductase NADPH—cytochrome-c2 reductase Leghemoglobin reductase

1.6.3: Oxygen	NADPH oxidase P91-PHOX Neutrophil cytosolic factor 1 Neutrophil cytosolic factor 2 Neutrophil cytosolic factor 4 dual oxidase Dual oxidase 1 Dual oxidase 2

1.6.5: Quinone or similar	NADH dehydrogenase

1.6.6: Nitrogenous group	Trimethylamine-N-oxide reductase

1.6.99: other	NADH dehydrogenase (quinone)

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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