Molybdopterin molybdotransferase

Molybdopterin molybdotransferase
Identifiers
EC number 2.10.1.1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Molybdopterin molybdotransferase (EC 2.10.1.1, MoeA, Cnx1) is an enzyme with systematic name adenylyl-molybdopterin:molybdate molybdate transferase (AMP-forming).[1][2][3] This enzyme catalyses the following chemical reaction

adenylyl-molybdopterin + molybdate molybdenum cofactor + AMP

Catalyses the insertion of molybdenum into the ene-dithiol group of molybdopterin.

References

  1. Nichols, J.D.; Rajagopalan, K.V. (2005). "In vitro molybdenum ligation to molybdopterin using purified components". J. Biol. Chem. 280: 7817–7822. doi:10.1074/jbc.M413783200. PMID 15632135.
  2. Nichols, J.D.; Xiang, S.; Schindelin, H.; Rajagopalan, K.V. (2007). "Mutational analysis of Escherichia coli MoeA: two functional activities map to the active site cleft". Biochemistry. 46 (1): 78–86. doi:10.1021/bi061551q. PMID 17198377.
  3. Llamas, A.; Otte, T.; Multhaup, G.; Mendel, R.R.; Schwarz, G. (2006). "The Mechanism of nucleotide-assisted molybdenum insertion into molybdopterin. A novel route toward metal cofactor assembly". J. Biol. Chem. 281 (27): 18343–18350. doi:10.1074/jbc.M601415200. PMID 16636046.
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