Mitochondrial fission factor

MFF

Identifiers

MFF, C2orf33, GL004, mitochondrial fission factor

External IDs

Gene ontology
Molecular function	• protein homodimerization activity • protein binding
Cellular component	• integral component of membrane • membrane • synaptic vesicle • peroxisome • synapse • mitochondrial outer membrane • cell junction • mitochondrion • integral component of mitochondrial membrane • cytoplasmic vesicle
Biological process	• mitochondrial fusion • mitochondrial fragmentation involved in apoptotic process • positive regulation of mitochondrial fission • mitochondrial fission • regulation of mitochondrion organization • regulation of peroxisome organization • protein targeting to mitochondrion • peroxisome fission • positive regulation of release of cytochrome c from mitochondria • mitochondrion morphogenesis • protein homooligomerization • release of cytochrome c from mitochondria • positive regulation of protein targeting to membrane
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


56947


n/a


ENSG00000168958


n/a


Q9GZY8


n/a

RefSeq (mRNA)

NM_001277061 NM_001277062 NM_001277063 NM_001277064 NM_001277065
NM_001277066 NM_001277067 NM_001277068 NM_020194


n/a

RefSeq (protein)

NP_001263990.1 NP_001263991.1 NP_001263992.1 NP_001263993.1 NP_001263994.1
NP_001263995.1 NP_001263996.1 NP_001263997.1 NP_064579.3


n/a

Location (UCSC)

n/a

PubMed search

^[1]

n/a

Mitochondrial fission factor (Mff) is a protein that in humans is encoded by the MFF gene.^[2]

Mff is an outer mitochondrial membrane protein that binds to the Drp1 GTPase that controls mitochondrial fission. The Mff-Drp1 complex promotes mitochondrial fission.^[3] Mff also regulates peroxisome morphology.^[4]

References