MLLT1
Protein ENL is a protein that in humans is encoded by the MLLT1 gene.[3]
Interactions
MLLT1 has been shown to interact with CBX8.[4]
References
Further reading
- Tkachuk DC, Kohler S, Cleary ML (1992). "Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias". Cell. 71 (4): 691–700. doi:10.1016/0092-8674(92)90602-9. PMID 1423624.
- Thirman MJ, Levitan DA, Kobayashi H, et al. (1995). "Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia". Proc. Natl. Acad. Sci. U.S.A. 91 (25): 12110–12114. doi:10.1073/pnas.91.25.12110. PMC 45386
. PMID 7991593.
- Rubnitz JE, Morrissey J, Savage PA, Cleary ML (1994). "ENL, the gene fused with HRX in t(11;19) leukemias, encodes a nuclear protein with transcriptional activation potential in lymphoid and myeloid cells". Blood. 84 (6): 1747–52. PMID 8080983.
- Yamamoto K, Seto M, Komatsu H, et al. (1993). "Two distinct portions of LTG19/ENL at 19p13 are involved in t(11;19) leukemia". Oncogene. 8 (10): 2617–25. PMID 8378076.
- Lavau C, Luo RT, Du C, Thirman MJ (2000). "Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice". Proc. Natl. Acad. Sci. U.S.A. 97 (20): 10984–10989. doi:10.1073/pnas.190167297. PMC 27135. PMID 10995463.
- García-Cuéllar MP, Zilles O, Schreiner SA, et al. (2001). "The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3". Oncogene. 20 (4): 411–419. doi:10.1038/sj.onc.1204108. PMID 11313972.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Nie Z, Yan Z, Chen EH, et al. (2003). "Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner". Mol. Cell. Biol. 23 (8): 2942–2952. doi:10.1128/MCB.23.8.2942-2952.2003. PMC 152562. PMID 12665591.
- Gué M, Sun JS, Boudier T (2006). "Simultaneous localization of MLL, AF4 and ENL genes in interphase nuclei by 3D-FISH: MLL translocation revisited". BMC Cancer. 6: 20. doi:10.1186/1471-2407-6-20. PMC 1388228. PMID 16433901.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Meyer C, Burmeister T, Strehl S, et al. (2007). "Spliced MLL fusions: a novel mechanism to generate functional chimeric MLL-MLLT1 transcripts in t(11;19)(q23;p13.3) leukemia". Leukemia. 21 (3): 588–590. doi:10.1038/sj.leu.2404542. PMID 17252016.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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(2) Zinc finger DNA-binding domains |
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| | (2.1) Nuclear receptor (Cys4) | | subfamily 1 | |
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| | subfamily 2 | |
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| | subfamily 3 | |
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| | subfamily 4 | |
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| | subfamily 5 | |
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| | subfamily 6 | |
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| | subfamily 0 | |
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| | (2.2) Other Cys4 | |
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| | (2.3) Cys2His2 | |
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| | (2.4) Cys6 | |
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| | (2.5) Alternating composition | |
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| | (2.6) WRKY | |
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| (4) β-Scaffold factors with minor groove contacts |
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| (0) Other transcription factors |
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see also transcription factor/coregulator deficiencies |
