Lysine 6-dehydrogenase
| Lysine 6-dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.4.1.18 | ||||||||
| CAS number | 89400-30-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Lysine 6-dehydrogenase (EC 1.4.1.18, L-lysine epsilon-dehydrogenase, L-lysine 6-dehydrogenase, LysDH) is an enzyme with systematic name L-lysine:NAD+ 6-oxidoreductase (deaminating).[1][2][3][4] This enzyme catalyses the following chemical reaction
- L-lysine + NAD+ (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + NADH + H+ + NH3 (overall reaction)
- (1a) L-lysine + NAD+ + H2O (S)-2-amino-6-oxohexanoate + NADH + H+ + NH3
- (1b) (S)-2-amino-6-oxohexanoate (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + H2O (spontaneous)
The enzyme is highly specific for L-lysine as substrate, although S-(2-aminoethyl)-L-cysteine can act as a substrate, but more slowly.
References
- ↑ Misono, H.; Nagasaki, S. (1982). "Occurrence of L-lysine ε-dehydrogenase in Agrobacterium tumefaciens". J. Bacteriol. 150 (1): 398–401. PMC 220128
. PMID 6801024. - ↑ Misono, H.; Uehigashi, H.; Morimoto, E.; Nagasaki, S. (1985). "Purification and properties of L-lysine ε-dehydrogenase from Agrobacterium tumefaciens". Agric. Biol. Chem. 49: 2253–2255. doi:10.1271/bbb1961.49.2253.
- ↑ Misono, H.; Hashimoto, H.; Uehigashi, H.; Nagata, S.; Nagasaki, S. (1989). "Properties of L-lysine ε-dehydrogenase from Agrobacterium tumefaciens". J. Biochem. (Tokyo). 105 (6): 1002–1008. PMID 2768207.
- ↑ Heydari, M.; Ohshima, T.; Nunoura-Kominato, N.; Sakuraba, H. (2004). "Highly stable L-lysine 6-dehydrogenase from the thermophile Geobacillus stearothermophilus isolated from a Japanese hot spring: characterization, gene cloning and sequencing, and expression". Appl. Environ. Microbiol. 70 (2): 937–942. doi:10.1128/aem.70.2.937-942.2004. PMC 348916. PMID 14766574.
External links
- Lysine 6-dehydrogenase at the US National Library of Medicine Medical Subject Headings (MeSH)
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