Long range pseudoknots

Long range pseudoknot
Secondary structure of the long range pseudoknot
Identifiers
Symbol ?
Rfam RF01086
Other data
RNA type Cis-reg
Domain(s) Eukaryote Prokaryote

A long range pseudoknot is a pseudoknot containing a long loop region, and may be a mechanism of translational control.

A long range pseudoknot is thought to negatively regulate the translation of the IF3-L35-L20 operon in E. coli. This operon encodes the translation initiation factor IF-3 and ribosomal proteins L35 and L20. In this example, the RNA-RNA interaction occurs between nucleotides separated by a 300 nucleotide loop region.[1]

A long range pseudoknot is also believed to be required for the activity of the Neurospora VS ribozyme.[2]

References

  1. Chiaruttini, C; M Milet; M Springer (1996). "A long-range RNA-RNA interaction forms a pseudoknot required for translational control of the IF3-L35-L20 ribosomal protein operon in Escherichia coli". EMBO J. 15 (16) (16): 4402–13. PMC 452164Freely accessible. PMID 8861967.
  2. Rastogi, T; T L Beattie; J E Olive; R A Collins (1996). "A long-range pseudoknot is required for activity of the Neurospora VS ribozyme". EMBO J. 15 (11) (11): 2820–25. PMC 450219Freely accessible. PMID 8654379.

External links

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