Chlordiazepoxide/clidinium bromide

Chlordiazepoxide/clidinium bromide
Combination of
Chlordiazepoxide Anxiolytic
Clidinium bromide Antimuscarinic
Clinical data
AHFS/Drugs.com Monograph
MedlinePlus a601036
ATC code A03CA02 (WHO)
Identifiers
PubChem (CID) 3080646
ChemSpider 2338393 YesY
  (verify)

Chlordiazepoxide/clidinium bromide (marketed as Librax) is a drug consisting of chlordiazepoxide and clidinium bromide and used to treat peptic ulcers, irritable bowel syndrome (IBS), and gastritis. It helps relieve stomach spasms, abdominal cramps, and anxiety related to gastric disorders.[1] Librax is a fixed ratio of these two medications and, as such, is not typically prescribed with an accompanying dosage, but rather directions on how many capsules to take per day. It comes in a capsule taken by mouth, usually three or four times daily, before meals and at bedtime.[1] Chlordiazepoxide is an anti-anxiety medication belonging to the benzodiazepine class.[2] Its use in IBS is thought to be due to its calming ability for patients that have IBS symptoms that are worsened by anxiety. Clidinium bromide is a synthetic quaternary ammonium antimuscarinic,[3] a sub-class of a family of drugs known as anticholinergics. It treats IBS by decreasing gastrointestinal motility.

Chlordiazepoxide can be habit-forming. Tolerance may develop with long-term or excessive use, making this medication less effective. This medication must be taken regularly to be effective. Stopping the drug suddenly can worsen the condition and cause withdrawal symptoms (anxiousness, sleeplessness, and irritability).[1]

See also

References

  1. 1 2 3 "Librax". MedlinePlus: US National library of medicine. Retrieved 31 May 2013.
  2. ↑ http://www.medscape.com/druginfo/monograph?cid=med&drugid=2226&drugname=Clidinium-Chlordiazepoxide+Oral&monotype=monograph&monographid=382078 MedScape - Chlordiazepoxide
  3. ↑ http://www.medscape.com/druginfo/monograph?cid=med&drugid=15881&drugname=Librax+(with+Clidinium)+Oral&monotype=monograph&monographid=384006 MedScape - Clidinium


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