Leslie Z. Benet

Leslie Z. Benet
Born May 17, 1937 (1937-05-17) (age 79)
Cincinnati, Ohio
Occupation UCSF (Department of Bioengineering and Therapeutic Sciences, Department of Pharmaceutical Chemistry)
Title Professor
Spouse(s) Carol
Website profiles.ucsf.edu/leslie.benet
Academic background
Alma mater University of California
Thesis title Thermodynamics of Chelation by Tetracyclines
Thesis year 1965
Doctoral advisor Jere Goyan
Academic work
Discipline Pharmacology
Sub discipline Pharmacokinetics, Pharmacodynamics, Bioequivalence
Institutions Washington State University, University of California

Leslie 'Les' Zachary Benet (May 17, 1937) is an influential pharmaceutical scientist[1] heading the UCSF's Benet Lab at the Department of Bioengineering and Therapeutic Sciences[2] and recipient of the Remington Medal for distinguished service to American pharmacy.

Early life and education

Leslie Zachary Benet was born on May 17, 1937 in Cincinnati, Ohio into a family of pharmacists. His father, Jonas and his uncle, Harry, opened Benet's Pharmacies in Cincinnati in the 1930s and in 1942 founded DARA Products, the first drug company to manufacture hypoallergenic dermatologicals.[3]

Benet received his B.A. (English, 1959), B.S. (Pharmacy, 1960), M.S. (Pharmaceutical Chemistry, 1962) from the University of Michigan and Ph.D. (Pharmaceutical Chemistry, 1965) from the University of California.[3]

Academic career

Benet's early work included noncompartmental methods for calculating clearance and volume of distribution.[4][5][6] His paper on the volume of distribution is the most highly cited article in the Journal of Pharmaceutical Sciences (cited more than 900 times out of 19,000 articles).[7] In 1986 he was a founder and first president of the American Association of Pharmaceutical Scientists.[8] For over twenty years, Benet chaired the Department of Pharmacy at the UCSF which, under his leadership, became the Department of Biopharmaceutical Sciences. He supervised more than 55 Ph.D. theses and 100 post-doc students. Benet regularly advised the FDA in proposing guidance in the field of bioequivalence.[9] His recent work extended the Biopharmaceutics Classification System, leading to the Biopharmaceutics Drug Disposition Classification System allowing the prediction of enzymes and transporters, transporter-enzyme interplay and transporter-transporter interplay for new molecular entities and drug-drug interactions for already marketed drugs.[10][11] Benet is listed as one of the "25 Top Pharmacy Professors" in the USA.[12]

Published works

Benet published over 550 articles in peer-reviewed journals, more than 100 book chapters, and seven books.

Honors and awards

Honorary degrees

Scientific/professional honors and awards

Teaching awards

References

  1. ↑ Faculdade de Farmácia (March 31, 2016). "Leslie Benet" (PDF) (in Portuguese). Universidade de Lisboa. Retrieved June 13, 2016.
  2. ↑ "Benet Lab". University of California, San Francisco. March 9, 2011. Retrieved May 20, 2016.
  3. 1 2 Smith, David E.; Rowland, Malcolm; Giacomini, Kathleen M.; Amidon, Gordon L (July 20, 2012). "Dedication to Professor Leslie Z. Benet: 50 Years of Scientific Excellence and Still Going Strong!" (PDF). Pharmaceutical Research. 29 (9): 2345–2353. doi:10.1007/s11095-012-0808-3. PMID 22814901. Retrieved May 20, 2016.
  4. ↑ Rowland, Malcolm; Benet, Leslie Z.; Graham, Garry G. (April 1973). "Clearance Concepts in Pharmacokinetics". Journal of Pharmacokinetics and Biopharmaceutics. 1 (2): 123–136. doi:10.1007/BF01059626. PMID 4764426.
  5. ↑ Benet, Leslie Z.; Galeazzi, Renato L. (August 1979). "Noncompartmental Determination of the Steady- State Volume of Distribution" (PDF). Journal of Pharmaceutical Sciences. 68 (8): 1071–1074. doi:10.1002/jps.2600680845. PMID 480170. Retrieved May 20, 2016.
  6. ↑ Benet, Leslie Z. (February 3, 2012). "Benet L Z and Galeazzi R L: Noncompartmental Determination of the Steady-State Volume of Distribution, J Pharm Sci 68, 1071–1074, 1979—the Backstory" (PDF). The AAPS Journal. 14 (2): 164–167. doi:10.1208/s12248-012-9326-9. PMC 3326156Freely accessible. PMID 22302585.
  7. ↑ Hammerlund-Udanaes, Margareta; Brouwer, Kim; Nakashima, Emi; Terasaki, Tetsuya (June 6, 2013). "Perspectives on a Pharmacokinetics Legend: C versus T (Contributions over Time)" (PDF). Journal of Pharmaceutical Sciences. 102 (9): 2889–2894. doi:10.1002/jps.23628. PMID 23744575. Retrieved May 20, 2016.
  8. ↑ Benet, Leslie (November 2013). I Am AAPS (Speech). 2013 AAPS Annual Meeting and Exposition. San Antonio, TX: AAPS (published Feb 5, 2014). Retrieved May 20, 2016.
  9. ↑ "Pharmaceutical Science and Clinical Pharmacology Advisory Committee". Food and Drug Administration. March 29, 2016. Retrieved May 20, 2016.
  10. ↑ Wu, Chi-Yuan; Benet, Leslie Z. (January 1, 2005). "Predicting Drug Disposition via Application of BCS: Transport/Absorption/ Elimination Interplay and Development of a Biopharmaceutics Drug Disposition Classification System". Pharmaceutical Research. 22 (1): 11–23. doi:10.1007/s11095-004-9004-4. PMID 15771225.
  11. ↑ Benet, Leslie Z.; Broccatelli, Fabio; Oprea, Tudor I. (August 5, 2011). "BDDCS Applied to Over 900 Drugs" (PDF). The AAPS Journal. 13 (4): 519–547. doi:10.1208/s12248-011-9290-9. PMC 3231854Freely accessible. PMID 21818695.
  12. ↑ Franklin, Barry (2016). "25 Top Pharmacy Professors". Medical Technology Schools. Retrieved May 20, 2016.
  13. ↑ http://www.uu.se/en/about-uu/traditions/prizes/honorary-doctorates/
  14. ↑ Reyes, Maribel; Benet, Leslie Z. (September 2011). "Effects of Uremic Toxins on Transport and Metabolism of Different Biopharmaceutics Drug Disposition Classification System Xenobiotics" (PDF). Journal of Pharmaceutical Sciences. 68 (8): 3831–3842. doi:10.1002/jps.22640. Retrieved May 20, 2016.

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