Leann Tilley

Leann Tilley is currently Professor of Biochemistry and Molecular Biology in the Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne.

Education and Awards

Following a BSc(Hons) in Biochemistry at the University of Melbourne, Tilley obtained her PhD in Biochemistry from the University of Sydney. She completed postdoctoral fellowships at Utrecht University in the Netherlands, the College de France in Paris, and the University of Melbourne, Australia, before joining La Trobe University. In 2011 she moved to the Department of Biochemistry and Molecular Biology at the University of Melbourne, Australia.[1]

Professor Tilley was awarded an Australian Research Council Georgina Sweet Australia Laureate Fellowship (2016-2020) to measure and model malaria parasites. This includes a role as an ambassador for women in science. Tilley's work has been recognised by the award of the title of Redmond Barry Distinguished Professor, University of Melbourne (2016), an Australian Research Council Australian Professorial Fellowship (2011-2015), the Bancroft-Mackerras Medal from the Australian Society for Parasitology [2] and the Beckman Coulter Discovery Award of the Australian Society for Biochemistry and Molecular Biology.[3] Her team was awarded the 2016 Eureka Award for for Infectious Diseases Research.

Research

Tilley's research focuses on the use of molecular approaches and imaging techniques to study the malaria parasite and its interactions with its host in an effort to develop novel therapies. Her scientific contributions have been in four main areas: 1) Establishing Imaging Facilities and Technologies. For example, Tilley has pioneered the application of methods such as Super-Resolution Optical Microscopy to studies of the malaria parasite. 2) Antimalarial Drug Action. For example, Tilley investigates the molecular basis of the resistance that is currently emerging to the antimalarial drug, artemisinin,[4][5] with a view to extending the use of a drug that saves millions of lives, 3) Studying the unusual trafficking path that brings P. falciparum virulence proteins to the host red blood cell surface, and 4) Determining the molecular basis of the amazing shape-changing properties of the sexual stage gametocyte.

She served as Director (2013-2014) and Deputy Director (2005-2012) of the Australian Research Council Centre of Excellence for Coherent X-ray Science (CXS).[6]

External Links

References

  1. ↑ http://www.biochemistry.unimelb.edu.au/research/res_tilley.html
  2. ↑ http://www.ozemalar.org/news/news_tilley_august2010.html Leann Tilley, La Trobe University, is the 2010 recipient of The Bancroft-Mackerras Medal (2010)
  3. ↑ http://www.asbmb.org.au/awards/tilley.html The 2011 Beckman Coulter Discovery Science Award: Leann Tilley
  4. ↑ Klonis, N; Xie, SC; McCaw, JM; Crespo-Ortiz, MP; Zaloumis, SG; Simpson, JA; Tilley, L (Mar 2013). "Altered temporal response of malaria parasites determines differential sensitivity to artemisinin.". Proc Natl Acad Sci U S A. 110 (13): 5157–62. doi:10.1073/pnas.1217452110. PMC 3612604Freely accessible. PMID 23431146.
  5. ↑ Dogovski, C; Xie, S; Burgio, G; Bridgford, J; Mok, S; McCaw, J; Chotivanich, K; Kenny, S; Gnadig, N; Straimer, J; Bozdech, Z; Fidock, D; Simpson, J; Dondorp, A; Foote, S; Klonis, N; Tilley, L (2015). "Targeting the cell stress response of Plasmodium falciparum to overcome artemisinin resistance.". PLoS Biology. 13: e1002132. PMID 25901609.
  6. ↑ http://www.coecxs.org/
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