LSM7

LSM7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3JCR
Identifiers
Aliases	LSM7, YNL147W, LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated
External IDs	MGI: 1913344 HomoloGene: 6781 GeneCards: LSM7
Gene ontology Molecular function • protein binding • RNA binding • U6 snRNA binding Cellular component • small nucleolar ribonucleoprotein complex • cytosol • catalytic step 2 spliceosome • spliceosomal tri-snRNP complex • U6 snRNP • U12-type spliceosomal complex • intracellular ribonucleoprotein complex • nucleoplasm • Lsm1-7-Pat1 complex • spliceosomal complex • U2-type prespliceosome • nucleus Biological process • mRNA splicing, via spliceosome • RNA processing • mRNA processing • exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay • RNA splicing Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51690	66094
Ensembl	ENSG00000130332	ENSMUSG00000035215
UniProt	Q9UK45	Q9CQQ8
RefSeq (mRNA)	NM_016199	NM_025349
RefSeq (protein)	NP_057283.1	NP_079625.1
Location (UCSC)	Chr 19: 2.32 – 2.33 Mb	Chr 10: 80.85 – 80.86 Mb
PubMed search	[1]	[2]
Wikidata

U6 snRNA-associated Sm-like protein LSm7 is a protein that in humans is encoded by the LSM7 gene.^[3][4][5]

Function

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM]^[5]

Interactions

LSM7 has been shown to interact with TACC1^[6][7] and LSM2.^[8][9]

References

Further reading