KMO (gene)

KMO
Identifiers
Aliases KMO, dJ317G22.1, kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
External IDs MGI: 2138151 HomoloGene: 2729 GeneCards: KMO
Genetically Related Diseases
obesity[1]
RNA expression pattern




More reference expression data
Orthologs
Species Human Mouse
Entrez

8564

98256

Ensembl

ENSG00000117009

ENSMUSG00000039783

UniProt

O15229

Q91WN4

RefSeq (mRNA)

NM_003679

NM_133809

RefSeq (protein)

NP_003670.2

NP_598570.1

Location (UCSC) Chr 1: 241.53 – 241.6 Mb Chr 1: 175.62 – 175.66 Mb
PubMed search [2] [3]
Wikidata
View/Edit HumanView/Edit Mouse

Kynurenine 3-monooxygenase is an enzyme that in humans is encoded by the KMO gene.[4][5]

Kynurenine 3-monooxygenase (KMO; EC 1.14.13.9) is an NADPH-dependent flavin monooxygenase that catalyzes the hydroxylation of the L-tryptophan metabolite L-kynurenine to form L-3-hydroxykynurenine.[supplied by OMIM][5] This is the first step in the degradation of Kyneurinine to Quinolinic acid. This pathway is involved in the activation of cytokine mediated changes in behavior due to inflammatory stimuli such as infections.[6]

References

  1. "Diseases that are genetically associated with KMO view/edit references on wikidata".
  2. "Human PubMed Reference:".
  3. "Mouse PubMed Reference:".
  4. Alberati-Giani D, Cesura AM, Broger C, Warren WD, Rover S, Malherbe P (Sep 1997). "Cloning and functional expression of human kynurenine 3-monooxygenase". FEBS Lett. 410 (2-3): 407–12. doi:10.1016/S0014-5793(97)00627-3. PMID 9237672.
  5. 1 2 "Entrez Gene: KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)".
  6. Dantzer R, O'Connor JC, Lawson MA, Kelley KW (2011), "Inflammation-associated Depression: From Serotonin to Kyneurenine", Psychoneuroendocrinology, 36 (3): 426–36, doi:10.1016/j.psyneuen.2010.09.012, PMID 21041030

Further reading


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