KDM6B

KDM6B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases KDM6B, JMJD3, lysine demethylase 6B
External IDs MGI: 2448492 HomoloGene: 18945 GeneCards: KDM6B
Orthologs
Species Human Mouse
Entrez

23135

216850

Ensembl

ENSG00000132510

ENSMUSG00000018476

UniProt

O15054

Q5NCY0

RefSeq (mRNA)

NM_001080424

NM_001017426

RefSeq (protein)

NP_001073893.1

NP_001017426.1

Location (UCSC) Chr 17: 7.84 – 7.85 Mb Chr 11: 69.4 – 69.41 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Lysine demethylase 6B is a protein that in humans is encoded by the KDM6B gene. [3]

Small molecule inhibition

A small molecule inhibition (GSK-J1) has been developed to inhibit jumonji domain of KDM6 histone demethylase family to modulate proinflammatory response in macrophage.[4]

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. ↑ "Entrez Gene: Lysine demethylase 6B". Retrieved 2016-04-09.
  4. ↑ Kruidenier, Laurens; Chung, Chun-wa; Cheng, Zhongjun; Liddle, John; Che, KaHing; Joberty, Gerard; Bantscheff, Marcus; Bountra, Chas; Bridges, Angela (2012-08-16). "A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response". Nature. 488 (7411): 404–408. doi:10.1038/nature11262. ISSN 1476-4687. PMC 4691848Freely accessible. PMID 22842901.

Further reading

  • Agger K, Cloos PA, Christensen J, Pasini D, Rose S, Rappsilber J, Issaeva I, Canaani E, Salcini AE, Helin K (2007). "UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development". Nature. 449 (7163): 731–4. doi:10.1038/nature06145. PMID 17713478. 


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