José Santiago

José Santiago may refer to:

José Santiago (1950s pitcher), known as "Pantalones", (b. 1928), Puerto Rican pitcher in the Major Leagues from 1954-1956
José Santiago (1960s pitcher), known as "Palillo", (b. 1940), Puerto Rican pitcher in the Major Leagues from 1963-1970
José Santiago (2000s pitcher) (b. 1974), Puerto Rican pitcher in the Major Leagues from 1997-2005
José Luis Santiago Vasconcelos (1957–2008), senior Mexican civil servant killed in an aviation accident
José L. Santiago (b. 1960), Puerto Rican sergeant major in the United States Marine Corps
Josian Santiago, José A. "Josian" Santiago Rivera, (b. 1957), Puerto Rican politician and mayor of Comerío

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