Influenza non-structural protein

Influenza non-structural protein (NS1)
Identifiers
Symbol Flu_NS1
Pfam PF00600
InterPro IPR000256

Influenza non-structural protein (NS1) is a homodimeric RNA-binding protein found in influenza virus that is required for viral replication. NS1 binds polyA tails of mRNA keeping them in the nucleus. NS1 inhibits pre-mRNA splicing by tightly binding to a specific stem-bulge of U6 snRNA.[1]

References

  1. Huang Y, Rios CB, Tejero R, Zimmerman DE, Krug RM, Montelione GT, Chien CY (1997). "A novel RNA-binding motif in influenza A virus non-structural protein 1". Nat. Struct. Biol. 4 (11): 891–895. doi:10.1038/nsb1197-891. PMID 9360601.

This article incorporates text from the public domain Pfam and InterPro IPR000256

This article is issued from Wikipedia - version of the 6/1/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.