ISG20

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1WLJ

Identifiers

Aliases

ISG20, CD25, HEM45, interferon stimulated exonuclease gene 20kDa, interferon stimulated exonuclease gene 20

External IDs

MGI: 1928895 HomoloGene: 31081 GeneCards: ISG20

Gene ontology
Molecular function	• 3'-5'-exoribonuclease activity • single-stranded DNA 3'-5' exodeoxyribonuclease activity • exoribonuclease II activity • metal ion binding • U3 snoRNA binding • U2 snRNA binding • RNA binding • nucleic acid binding • U1 snRNA binding • nuclease activity • exonuclease activity • hydrolase activity
Cellular component	• cytoplasm • Cajal body • PML body • nucleoplasm • nucleolus • nucleus
Biological process	• immune system process • response to virus • RNA catabolic process • negative regulation of viral genome replication • DNA catabolic process, exonucleolytic • defense response to virus • type I interferon signaling pathway • rRNA processing • innate immune response • cell proliferation • RNA phosphodiester bond hydrolysis, exonucleolytic
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


3669


57444

Ensembl


ENSG00000172183


ENSMUSG00000039236

UniProt


Q96AZ6


Q9JL16

RefSeq (mRNA)

NM_001303233 NM_001303234 NM_001303235 NM_001303236 NM_001303237
NM_002201


NM_001113527 NM_001291220 NM_001291221 NM_020583

RefSeq (protein)


NP_001290162.1 NP_001290163.1 NP_001290165.1 NP_002192.2


NP_001106999.1 NP_001278149.1 NP_001278150.1 NP_065608.2

Location (UCSC)

Chr 15: 88.64 – 88.66 Mb

Chr 7: 78.91 – 78.92 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Interferon-stimulated gene 20 kDa protein is a protein that in humans is encoded by the ISG20 gene.^[3]^[4]^[5]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Gongora C, David G, Pintard L, Tissot C, Hua TD, Dejean A, Mechti N (Aug 1997). "Molecular cloning of a new interferon-induced PML nuclear body-associated protein". The Journal of Biological Chemistry. 272 (31): 19457–63. doi:10.1074/jbc.272.31.19457. PMID 9235947.
↑ Mattei MG, Tissot C, Gongora C, Mechti N (Jun 1998). "Assignment of ISG20 encoding a new interferon-induced PML nuclear body-associated protein, to chromosome 15q26 by in situ hybridization". Cytogenetics and Cell Genetics. 79 (3-4): 286–7. doi:10.1159/000134745. PMID 9605874.
↑ "Entrez Gene: ISG20 interferon stimulated exonuclease gene 20kDa".

Pentecost BT (Jan 1998). "Expression and estrogen regulation of the HEM45 MRNA in human tumor lines and in the rat uterus". The Journal of Steroid Biochemistry and Molecular Biology. 64 (1-2): 25–33. doi:10.1016/S0960-0760(97)00140-4. PMID 9569007.
Nguyen LH, Espert L, Mechti N, Wilson DM (Jun 2001). "The human interferon- and estrogen-regulated ISG20/HEM45 gene product degrades single-stranded RNA and DNA in vitro". Biochemistry. 40 (24): 7174–9. doi:10.1021/bi010141t. PMID 11401564.
Izmailova E, Bertley FM, Huang Q, Makori N, Miller CJ, Young RA, Aldovini A (Feb 2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nature Medicine. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042.
Espert L, Degols G, Gongora C, Blondel D, Williams BR, Silverman RH, Mechti N (May 2003). "ISG20, a new interferon-induced RNase specific for single-stranded RNA, defines an alternative antiviral pathway against RNA genomic viruses". The Journal of Biological Chemistry. 278 (18): 16151–8. doi:10.1074/jbc.M209628200. PMID 12594219.
Horio T, Murai M, Inoue T, Hamasaki T, Tanaka T, Ohgi T (Nov 2004). "Crystal structure of human ISG20, an interferon-induced antiviral ribonuclease". FEBS Letters. 577 (1-2): 111–6. doi:10.1016/j.febslet.2004.09.074. PMID 15527770.

PDB gallery

1wlj: human ISG20

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ISG20

References

Further reading