IFT20

IFT20
Identifiers
Aliases	IFT20
External IDs	MGI: 1915585 HomoloGene: 49559 GeneCards: IFT20
Gene ontology Molecular function • protein binding • opsin binding • Rab GTPase binding Cellular component • cis-Golgi network • Golgi membrane • centriole • dendrite terminus • ciliary base • ciliary basal body • motile cilium • primary cilium • cytoplasm • photoreceptor connecting cilium • cytoskeleton • cell projection • ciliary tip • extracellular exosome • photoreceptor outer segment • centrosome • stereocilium • microvillus • intraciliary transport particle B • cilium • Golgi apparatus • kinociliary basal body Biological process • cilium assembly • smoothened signaling pathway • cell projection organization • neurogenesis • neural precursor cell proliferation • photoreceptor cell outer segment organization • cardiac muscle cell differentiation • kidney development • protein localization to Golgi apparatus • opsin transport • regulation of canonical Wnt signaling pathway • visual learning • regulation of autophagosome assembly • regulation of cilium assembly • establishment of protein localization to plasma membrane • establishment of planar polarity • inner ear receptor stereocilium organization • protein localization to cilium • centrosome localization • cochlea development • intraciliary transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	90410	55978
Ensembl	ENSG00000109083	ENSMUSG00000001105
UniProt	Q8IY31	Q61025
RefSeq (mRNA)	NM_174887 NM_001267774 NM_001267775 NM_001267776 NM_001267777 NM_001267778	NM_018854
RefSeq (protein)	NP_001254703.1 NP_001254704.1 NP_001254705.1 NP_001254706.1 NP_001254707.1 NP_777547.1	NP_061342.1
Location (UCSC)	Chr 17: 28.33 – 28.34 Mb	Chr 11: 78.54 – 78.54 Mb
PubMed search	[1]	[2]
Wikidata

Intraflagellar transport protein 20 homolog is a protein that in humans is encoded by the IFT20 gene.^[3] The gene is composed of 6 exons and is located on human chromosome 17p11.1. This gene is expressed in human brain, lung, kidney and pancreas, and lower expression were also detected in human placenta, liver, thymus, prostate and testis.^[4]

Intraflagellar transport (IFT), in which molecular motors and IFT particle proteins participate, is very important in assembling and maintaining many cilia/flagella, such as the motile cilia that drive the swimming of cells and embryos, the nodal cilia that generate left-right asymmetry in vertebrate embryos, and the sensory cilia that detect sensory stimuli in some animals.^[4] IFT20 subunit of the particle is localized to the Golgi complex in addition to the basal body and cilia where all previous IFT particle proteins had been found. In living cells, fluorescently tagged IFT20 is highly dynamic and moves between the Golgi complex and the cilium as well as along ciliary microtubules.^[5] IFT20 has been shown to interact with SPEF2 in the testis, and plays a role in sperm motility.^[6]

References

Further reading