Hepacivirin

Hepacivirin
Identifiers
EC number 3.4.21.98
CAS number 149885-80-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Hepacivirin (EC 3.4.21.98, Cpro-2, hepatitis C virus NS3 serine proteinase, NS3-4A serine proteinase complex) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction:

Hydrolysis of four peptide bonds in the viral precursor polyprotein, commonly with Asp or Glu in the P6 position, Cys or Thr in P1 and Ser or Ala in P1'

This enzyme is encoded by the genome of the viruses of the hepatitis C group.

References

  1. Kim, J.L.; Morgenstern, K.A.; Lin, C.; Fox, T.; Dwyer, M.D.; Landro, J.A.; Chambers, S.P.; Markland, W.; Lepre, C.A.; O'Malley, E.T.; Harbeson, S.L.; Rice, C.M.; Murcko, M.A.; Caron, P.R.; Thomson, J.A. (1996). "Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide". Cell. 87: 343–355. doi:10.1016/s0092-8674(00)81351-3. PMID 8861917.
  2. Rice, C.M.; Rawlings, N.D.; Woessner, J.F. (1998). "Hepatitis C virus polyprotein peptidase". In Barrett, A.J. Handbook of Proteolytic Enzymes. London: Academic Press. pp. 272–277.
This article is issued from Wikipedia - version of the 5/20/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.