HLA-B45
Further information: HLA-serotype tutorial
 | ||
| HLA-B (alpha)-β2MG with bound peptide | ||
| major histocompatibility complex (human), class I, B45 | ||
| Alleles | B*4501, 4502 . . | |
| Structure (See HLA-B) | ||
| Shared data | ||
| Locus | chr.6 6p21.31 | |
HLA-B45 (B45) is an HLA-B serotype. The serotype identifies the B*45 gene-allele protein products of HLA-B.[1]
B45 is a split antigen of the broad antigen B12, and is a sister type of B44.
Serotype
| B*45 | B45 | B12 | B45 | Sample |
| allele | % | % | % | size (N) |
| *4501 | 93 | 1 | 1 | 2307 |
| *4502 | 75 | 4 | ||
| Alleles link-out to IMGT/HLA Databease at EBI | ||||
Alleles
It was reported that a novel haplotype was found in Italian bone marrow doners. A2-CW*1601-B45- DRB1*1101-DRB3*0301-DQA1*0102-DQB1*0502. This haplotype indicates possible very recent ancestry from Africa, with the Cw*1601 and B45 components and also with the DR11-DQ5.2 component both extremely rare in Europe.[3]
References
- ↑ Marsh SG, Albert ED, Bodmer WF, et al. (2005). "Nomenclature for factors of the HLA system, 2004". Tissue Antigens. 65 (4): 301–69. doi:10.1111/j.1399-0039.2005.00379.x. PMID 15787720.
- ↑ derived from IMGT/HLA
- ↑ Daielli C, Salvaneschi L, Ghidini G, Ambroselli F, Gatti C, Martinetti M (April 1996). "A novel Italian haplotype predominates in HLA-B45-positive bone marrow donors: HLA-A2, CW*1601, B45, DRB1*1101, DRB3*0301, DQA1*0102, DQB1*0502". Tissue Antigens. 47 (4): 341–3. doi:10.1111/j.1399-0039.1996.tb02564.x. PMID 8773326.
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