Glypican 2

GPC2

Identifiers

GPC2, Glypican 2

External IDs

Gene ontology
Molecular function	• heparan sulfate proteoglycan binding
Cellular component	• membrane • proteinaceous extracellular matrix • plasma membrane • extracellular space • extracellular region • lysosomal lumen • endoplasmic reticulum • Golgi lumen • anchored component of membrane
Biological process	• glycosaminoglycan metabolic process • retinoid metabolic process • glycosaminoglycan catabolic process • glycosaminoglycan biosynthetic process • neuron differentiation • smoothened signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


221914


71951


ENSG00000213420


ENSMUSG00000029510


Q8N158


Q8BKV1

RefSeq (mRNA)


NM_152742


NM_172412

RefSeq (protein)


NP_689955.1


NP_766000.1

Location (UCSC)

PubMed search

^[1]

^[2]

Glypican 2 (GPC2), also known cerebroglycan, is a protein which in humans is encoded by the GPC2 gene.^[3]^[4]

Function

Cerebroglycan is a glycophosphatidylinositol-linked integral membrane heparan sulfate proteoglycan found in the developing nervous system. Cerebroglycan participates in cell adhesion and is thought to regulate the growth and guidance of axons.^[5] Cerebroglycan has especially high affinity for laminin-1.^[6]

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Stipp CS, Litwack ED, Lander AD (January 1994). "Cerebroglycan: an integral membrane heparan sulfate proteoglycan that is unique to the developing nervous system and expressed specifically during neuronal differentiation". J. Cell Biol. 124 (1–2): 149–160. doi:10.1083/jcb.124.1.149. PMC 2119891. PMID 8294498.
↑ "Entrez Gene: GPC2 glypican 2".
↑ Ivins JK, Litwack ED, Kumbasar A, Stipp CS, Lander AD (April 1997). "Cerebroglycan, a developmentally regulated cell-surface heparan sulfate proteoglycan, is expressed on developing axons and growth cones". Dev. Biol. 184 (2): 320–332. doi:10.1006/dbio.1997.8532. PMID 9133438.
↑ Herndon ME, Stipp CS, Lander AD (February 1999). "Interactions of neural glycosaminoglycans and proteoglycans with protein ligands: assessment of selectivity, heterogeneity and the participation of core proteins in binding". Glycobiology. 9 (2): 143–155. doi:10.1093/glycob/9.2.143. PMID 9949192.

GPC2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

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